Description overdue on 09/10/2014

• Composition
• Product form
• Pharmacological action
• Pharmacokinetics and pharmacodynamics
• Indications
• Contraindications
• Side effects
• Instructions for use Gordoksa (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Synonyms
• Analogs
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

The preparation contains the active substance in the composition aprotinin   and additional components: benzyl alcohol . NaCl , Water for injection.

Product form

Gordoks produced in the form of a solution for intravenous administration of 10,000 KIU / mL. Contained in a vial of colorless glass, which is a point for the fault. Ampoules stacked in a plastic tray 5 vials.

Pharmacological action

The tool has on the body antiproteaznoe, antifibrinolytic effects. Due to the influence of the active substance, aprotinin , Inhibits the activity of a number of proteolytic enzymes. Inhibitor is Aprotinin kallikrein . Under its influence released inflammatory cytokines, also helps to maintain homeostasis substance glycoproteins.

When using aprotinin surgical practice   using AIC marked decrease in inflammatory processes, which in turn, reduces blood loss, and reduces the need for blood transfusion.

Pharmacokinetics and pharmacodynamics

After the drug is administered intravenously to a patient, atropine   actively distributed in the extracellular space, whereby the concentration in blood decreases rapidly. Terminal half-life is from 5 to 10 hours.

With the plasma proteins bound on the average 80% aprotinin. A drug that is in a free form, accounts for about 20% antifibrinolytic activity .

Total clearance is equal to about 40 ml per minute.

Basically marked accumulation of aprotinin in the kidneys, less material accumulates in the cartilage. In the human brain there is a very low concentration of active ingredient in liquor aprotinin barely penetrates. Through the placenta gets a small amount of the active substance Gordoksa.

Metabolized active substance by lysosomal enzymes in kidneys within 48 hours from 25 to 40% of aprotinin in urine is in the form of inactive metabolites.

Indications

Description Gordoksa indication for use as follows:

• acute manifestations pancreatitis   (agent used in the complex treatment);
• chronic form pancreatitis   (with frequent relapses and severe disease);
• pancreatitis Which developed as a result of surgical interventions and traumas;
• Primary bleeding on the background hyperfibrinolysis   (after injuries, operations, before and after birth, with polimenoree );
• pancreatonecrosis ;
• diagnostic and testing operations on the pancreas;
• prevention of post-operative non-specific Mumps   after operation;
• angioedema ;
• symptoms of shock (trauma, toxicity, hemorrhagic);
• tissue injury (deep, extensive).

Also shown Gordoksa use as adjuvant therapy in coagulopathy At which secondary notes hyperfibrinolysis , Severe bleeding. This tool is also used as prevention of pulmonary embolism   and bleeding after surgery.

Contraindications

Do not use Gordoks people who marked intolerance to aprotinin or any other components of this drug. You also can not use in patients with DIC At pregnancy   (first trimester).

Side effects

As a rule, the application of funds Gordoks patients were observed adverse events. In rare cases may occur dyspeptic   and Allergic effects . Sometimes therapy Gordoksom holds a manifestation of muscle pain, changes Blood Pressure .

Allergic symptoms   the first administration of the drug are rare, the incidence of development increases (approximately 5%) at the re-introduction means. The probability of severe allergic or anaphylactic symptoms increased if over 6 months of treatment Gordoksom conducted twice or more.

Instructions for use Gordoksa (method and dosage)

If the patient is assigned Gordoks, instructions for use when it is used should be carefully observed. Agent is administered intravenously, slowly, when administered to a permissible maximum speed of 5 to 10 ml per minute. When the drug is administered to the patient, it should at this time lie at the back. Gordoks inserted through the main vein, while for administration of other drugs, they are not used.

Initially, about 10 minutes before the main injection, each patient is given a test dose Gordoksa, which is 1 ml. If there are no allergic reactions, the main dose administered funds.

For an adult starting dose is 0, 5-2 million. KIE, its drive for 15-20 minutes. The maintenance dose is 200 thousand. KIE Gordoksa after 4 - 6 hours. With the gradual disappearance of the symptoms can be reduced by a maintenance dose of up to 500 thousand. KIE daily.

If your doctor prescribes treatment Gordoksom children, the dose is calculated according to body weight: 1 kg - 20 thousand. KIE funds.

Overdose

If overdose patient can develop various allergic reactions in severe cases - anaphylactic shock . If a person develops symptoms of intolerance means, then the application should suspend Gordoksa then practiced symptomatic treatment.

Cooperation

If you add aprotinin   to heparinized blood marked increase in the period of whole blood clotting.

When used in conjunction with Gordoks Reomakrodeksom Whereas there is a growing sensitizing effects.

Aprotinin   inhibitory effect Urokinase . streptokinase . alteplase .

Aprotinin   - A weak inhibitor of serum pseudocholinesterase. If you apply the tools at the same time can slow down metabolism suxamethonium chloride Also amplified muscle relaxation May develop apnea .

Terms of sale

Means prescription.

Storage conditions

Gordoks refers to the list of B, means should be stored at a temperature between 15 and 30 ° C.

Shelf life

The drug can be stored 5 years.

Cautions

Before treatment is necessary to conduct skin tests to determine individual sensitivity to human Aprotinin .

If a history indicated allergic reactions , Before starting treatment aprotinin   should take the blockers of histamine H1-receptors and corticosteroids.

When the manifestation DIC   and hyperfibrinolysis   Aprotinin is permissible to take only after removal of all symptoms of DIC, and in the case marked prophylactic effect Heparin .

Caution means applied to those patients who for 2-3 days prior to treatment received muscle relaxants .

When used in the treatment Gordoksa, especially during re-treatment may experience anaphylactic or allergic reactions. Therefore, people who are prone to allergies should clearly determine the extent of the benefits and risks.

The composition has a means Gordoks benzyl alcohol, so that the maximum daily dose should not exceed 90 mg per kg of body weight.

Gordoks not a substitute for heparin.

After the ampoule was opened and the contents should be used, with repeated use of the administered solution impossible to open the ampoule.

It is not advisable to mix Gordoks with other drugs.

Synonyms

Contrycal .

Analogs Gordoksa

Analogs Gordoks drugs - are drugs Aprotinin . Traksolan . Aproteks . Ingitrila . AERUS . But the use of these drugs as a substitute Gordoks only after doctor's approval.

Babies

Manual holds information that the drug should not be used for children and adolescents under the age of eighteen years of age, as there is no clear data on safety and efficacy.

During pregnancy and lactation

Gordoks be used to treat expectant mothers only after first trimester . However, in the later stages of pregnancy means applies solely on prescription, and with clear indications for its use. In this important constant medical supervision in the treatment of this drug.

Clinical data on the safety of the vehicle during the period breastfeeding no.

Reviews

Reviews Gordokse that occur in the network, basically show the positive experience of using funds for the treatment of acute forms of pancreatitis. Reportedly, in particular that in acute pancreatitis Gordoks 2-3 days relieves acute manifestations of the disease. Reviews indicate that Gordoks is used to treat children, but the appointment of a specialist.

Price Gordoksa

The tool is often administered in a number of diseases such as pancreatitis. Price Gordoksa pharmacies on average 5,100 rubles a package of 25 vials. Buy in Moscow one vial can be as low as 180 to 250 rubles.