Description overdue on 08/18/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Lidevina (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

As part of a single tablet contains 300 Lidevina CIM. nicotinamide   or Vitamin B3 500 mcg.   adenine   or vitamin B4 And 500 mg. active active compound disulfiram .

As auxiliary compounds present in the composition of the drug: povidone, magnesium stearate, sodium carboxymethylcellulose, and microcrystalline cellulose.

Product form

The drug is produced in the form of round white pills ploskotsilindricheskoy form (allowed blotches) or cream, coated with one side of the cross-shaped mark.

Pharmacological action

Lidevin belong to the group of medicines which are used in the treatment   Alcoholism , and substance abuse and addiction . The drug has about alcohol effects Blocking acetaldehyde dehydrogenase (liver enzymes).

Pharmacodynamics and pharmacokinetics

This combination drug containing in its composition B vitamins , and disulfiram   actively used in the treatment alcohol   and drug dependence . Since disulfiram   It is inhibitor   such as the liver enzyme acetaldehyde dehydrogenase , Lidevin can act on it, namely the block to increase the production acetaldehyde Which, in turn, relate to metabolites ethanol .

Due to the effects of acetaldehyde   the drug causes an unpleasant reaction in patients and negative feelings with alcohol, which may be expressed as a sudden rush of blood to the face, vomiting, tachycardia, lowering blood pressure, and nausea. As a result, a person itself is formed   conditioned reflex   aversion to the smell and taste of the more alcoholic beverages.

Within 12 hours after administration Lidevina the maximum effect of the drug, which continues for a further 14 days after the course of therapeutic treatment. It should be particularly emphasized that the activity of the active compound disulfiram   in combination with vitamins Group B effectively fights alcoholism .

It is also noteworthy that the pronounced clinical effect of the drug is seen even when using very small doses of alcohol. In comparison with similar drugs Lidevin stands out relatively few side effects and contraindications. The drug is used not only during treatment, but also in the prevention of gipovitaminozov , and Neuropathy against the background of alcoholism.

Indications

Lidevin recommended for use in the treatment and prevention Alcoholism , Including chronic and substance abuse   and drug dependence . In addition, this preparation is used for preventive purposes.

Contraindications

The drug has the following absolute contraindications:

• hypersensitivity;
• diseases of the eye and ear , eg, neuritis or glaucoma;
• emphysema;
• tuberculosis;
• diabetes ;
• severe diseases of the cardiovascular system ;
• epilepsy ;
• bronchial asthma ;
• exacerbation stomach ulcers ;
• polyneuritis ;
• pregnancy ;
• duodenal ulcer In the acute stage;
• hepatic failure ;
• oncological diseases ;
• thyrotoxicosis .

Special care is allowed to use the drug in acute medical need and under the supervision of doctors in the   remission of peptic ulcer disease , After an psychosis and circulatory disorders And also in the elderly and in the compensation stage diseases of the cardiovascular system.

Side effects

During treatment Lidevin can cause such side effects as:

• headache;
• hepatitis;
• confusion;
• angina;
• arrhythmia;
• an unpleasant metallic taste in the mouth;
• asthenia;
• allergic reactions;
• optic neuritis;
• thrombosis;
• swelling of the brain;
• collapse;
• convulsions;
• polyneuritis.

Instructions for use Lidevina (method and dosage)

In accordance with the instructions for use Lidevina pills taken strictly on the 24 hours after the last drink. The recommended dose of the drug is 125-500 mg.

After a maximum of 10 days, medical professionals carry out the patient intake of disulfiram-alcohol test, the results of which is determined by the effectiveness of therapeutic treatment. To secure the effectiveness of further patients can take 125-200 mg. drug per day for several years.

Overdose

Until now, cases of overdose Lidevinom official sources are not mentioned. However, it is worth remembering that the concomitant use of medication and alcohol can cause a very serious condition, for example, the patient may fall into whom , get collapse   or serious neurological complication.

Cooperation

Lidevin strictly forbidden to take with alcohol as well as drugs and drinks that contain even small doses ethanol.   Behavioral problems and impaired coordination can occur when using the drug in conjunction with Isoniazid .

Symptoms such as confusion   and delirious disorders   It arises in the joint application Lidevina and such drugs as a Ornidazole, tinidazole, metronidazole   and Seknidazol.   To avoid the toxic effect of the drug is not desirable to use in conjunction with Phenytoin .

Caution should be used and Lidevin Warfarin Since increases the risk of bleeding, Benzodiazepine , because of inhibition of oxidative metabolism, and Theophylline So as not to slow biotransformation active active compound, a member of the latter drug. Using Antidepressants   together with disulfiram   intolerance of alcohol may increase.

Terms of sale

Lidevin implement a prescription.

Storage conditions

Because the drug is included in List B, it should be stored out of reach of children at a temperature of 25 ° C.

Shelf life

3 years.

Cautions

Before using the drug the patient should be advised of the possibility of hazardous reactions while the use of alcohol and Lidevina. With care prescribe a drug to patients with hypothyroidism   and renal failure .

Analogs

By the same Lidevinu drugs include:

• Antabuse;
• Teturam;
• Disulfiram;
• Esperal;
• Colm.

During pregnancy and lactation

The drug may not be used during pregnancy   or when breastfeeding .

Reviews Lidevine

On the Internet you can find plenty of both negative and positive responses of physicians and patients about this preparation. It is worth noting that often the people on the forums asking the question about what the drug more effectively struggles with alcoholism or Lidevin Colm .

Many people prefer to use the latter drug, because it has far fewer contraindications and side effects. We can say that in general reviews Lidevin the treatment of alcoholism are positive. Although many patients are afraid to take the drug because of possible side effects.

Price Lidevina where to buy

The cost of the drug varies depending on the region, but the average price Lidevina (packaging of 20 tablets) varies from 800 to 1000 rubles.

Buy in Moscow Lidevin possible at an average price of 900 rubles.