Description overdue on 04/29/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions on Nicorette (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Babies
• With alcohol
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

Chewing gum Nicorette   It contains as active substance nicotine   (2 mg or 4 mg). As additional substances it contains sorbitol . sodium Na . carbonate anhydrous Na . glycerol . semisint . aromatic additive .

AT Nicorette patch   contains nicotine And also further substances acrylate copolymer . acrylic adhesive pp . Medium-chain triglycerides . sodium croscarmellose . polyethylene terephthalate film 19 microns . aluminum acetylacetonate . potassium hydroxide . a polyethylene terephthalate film of 100 microns .

Product form

The drug comes in the form gum . patch And produced Nicorette Inhaler .

Chewing gum   discharged with nicotine content, and 2 mg to 4 mg, in packages containing 30 pads.

Patch   (transdermal therapeutic system) has a surface area
10 square meters. cm., rectangular, zaokruglennye edge. On one side - the inscription «nicorette», the second side - adhesive, white color, it covers the protective film. Produced with varying amounts of the active ingredient (5 mg, 10 mg, 15 mg, 25 mg) in boxes of cardboard 7 and 14 pcs.

Inhaler   It includes a plastic mouthpiece and replaceable cartridges containing nicotine.

Also available sublingual tablets with lemon flavor . They are round, are white, flat on one side of the tablet embossed inscription «N2".

Pharmacological action

When withdrawal syndrome in humans, sharply renounced nicotine products, there is a series of symptoms characteristic of the so-called withdrawal. It dysphoria   or a bad mood, irritability, insomnia . anxiety . distraction , Increased appetite, decreased heart rate.

The drug is indicated for replacement therapy in the treatment of tobacco dependence. Nicorette helps to alleviate withdrawal symptoms in people who have given up smoking. This is accomplished by providing the human body ionized nicotine . But this blood plasma level of nicotine does not have a high value.

When using Nicorette gum, nicotine contained therein is slowly released and slowly absorbed into the body. Systemic effects of nicotine does not occur, as when passing through the liver, it quickly collapses.

According to clinical studies, nicotine replacement therapy can effectively help heavy smokers to refrain from smoking.

Pharmacodynamics and pharmacokinetics

Nicotine, which enters the body of the chewing gum into the bloodstream within 5-7 minutes, absorbed through the oral mucosa. The highest concentration of nicotine marked 30 minutes after the start of rumination. Basically nicotine withdrawal liver, as it is metabolized in the kidneys and lungs. Approximately 10 to 30% is excreted unchanged in the urine.

Patch after use the highest concentration of nicotine in the blood plasma is observed after about 9 hours. If the Nicorette patch is applied correctly, the largest concentration of nicotine is celebrated in the evening when, as a rule, there is a strong desire to smoke.

Nicotine binds with the blood of no more than 5%. Smokers who are ill chronic renal failure   and treated hemodialysis , The concentration of nicotine in the blood increases. Older people total clearance of nicotine is slightly reduced, but dose adjustment is not required.

Indications

Nicorette applied in the following cases:

• Treatment of dependence on smoking in those who have a clear motivation for such therapy.
• Reducing the severity of withdrawal symptoms when a person needs to stop smoking for a certain period of time.
• Reducing the number of cigarettes smoked, if a person can not give up smoking completely.

Contraindications

Do not treat Nicorette, if a person is marked intolerance to substances in its composition. Not practiced treatment with children.

Side effects

The intensity of side effects depends on the dose of nicotine obtainable person. They are generally similar to the side effects that are observed when smoking tobacco.

Sometimes symptoms that are not related to the effects of nicotine on the body, and are signs of abstinence. It headache . dizziness . weakness , Fatigue and others.

When using Nicorette, the following side effects:

• The functions of the digestive tract: nausea, vomiting, dyspepsia , Hiccups.
• The functions of the circulatory system: atrial fibrillation, tachycardia .
• Common effects: pain in the masticatory muscles, allergic reactions, ulcers in the mouth and throat.
• About 20% of people using the patch note minor cutaneous manifestation of local reactions in the first days of treatment.

Instructions on Nicorette (method and dosage)

The following rules must be carefully observed to achieve the desired effect.

Instructions for use chewing gum   following: originally accepted Nicorette chewing gum   2 mg. Every day takes 8-12 gum pads. If a smoker is noted heavy dependence on tobacco (previously he smoked 20 cigarettes a day), it is advisable to apply for replacement therapy Nicorette 4mg. At night you can not chew more than 24 of gum.

If a person seeks to stop smoking completely, it is necessary to use the gum for at least 3 months, after which the dose is gradually reduced. When the dose will be 1-2 pads per day, the drug can be canceled.

Chewing gum is recommended whenever there is a pronounced desire to smoke. If you are using a treatment regimen for a month and a half the number of cigarettes has not decreased, treatment strategy should be changed.

Tablets Nicorette apply sublingually and held until complete dissolution. The dosage is adjusted individually. People with low dependence on a time sufficient to take one tablet 2 mg, people with severe dependence can increase the dose to two tablets 2 mg. The day can not be used for more than 30 pills of 2 mg.

Instructions on Nicorette patch   next. In the morning it is applied to intact skin, remove the patch before going to bed. Accordingly, during sleep nicotine into the body is not supplied. The first stage is used per day patch 25 mg. This stage lasts 8 weeks. Then for two weeks, you need to use the patch 15 mg. The next two weeks has been used for the patch 10 mg.

If nicotine addiction is not strong, the treatment starts with the use of the patch 15 mg (treatment lasts for 8 weeks). The next four weeks applied patch 10 mg.

Treatment average lasts about 3 months. Sometimes it takes a longer period, however, use the patch without interruption longer than six months is not recommended.

The patch is pasted on a dry and clean skin without hair (thigh, chest, shoulder). Every day you need to change the place of application.

Before applying you need to wash your hands, cut packaging and carefully glue the patch, trying not to touch the sticky surface.

Overdose

When Nicorette overdose symptoms observed are the same as for nicotine poisoning:

• nausea ;
• headache or dizziness;
• abdominal pain and frustration of a chair;
• hyperhidrosis ;
• hypotension, weakness;
• arrhythmia ;
• shortness of breath;
• occurrence of seizures.

Keep in mind that therapeutic doses intended for adults, can be fatal for young children.

Smoking and the use of parallel Nicorette may cause nicotine overdose . Overdose is possible when using multiple patches at once, as well as the simultaneous use of different forms of Nicorette.

In case of overdose immediately cease the use of nicotine and symptomatic therapy.

Cooperation

As a result of smoking cessation may increase the blood concentration of a number of drugs: clozapine . theophylline . flecainide . imipramine And other drugs with a low therapeutic index.

There is evidence that smoking may change the metabolism flecainide   and pentazocine .

Terms of sale

Pharmacies vehicle is sold without a prescription.

Storage conditions

Nicorette should be protected from children, the drug should be stored at a temperature between 15 and 25 degrees Celsius.

Shelf life

Nicorette chewing gum washes saved 2 years, tablets - 3 years, the plaster - 3 years.

Cautions

In the treatment of chewing gum people with dentures may experience inconvenience and discomfort. If you use Nicorette people suffering from cardiovascular disease, their condition must strictly control the treating physician.

The drug is prescribed with care for people with diseases of the liver and kidneys , Patients with ulcer . hyperthyroidism . pheochromocytoma .

If smoking the patient refuses to insulin diabetes , It is necessary to adjust the dose received insulin.

When quitting smoking a person can gain excess weight . With the use of Nicorette this process can be brought under control.

If there is a need to stop smoking for some time, the medication should be taken as soon as there is a desire to smoke.

There has been no negative impact on the ability to drive vehicles or to work with the exact mechanisms.

Analogs

Drug analogs are other drugs that are composed of nicotine. It Nikotinell . Nicotine USP . Nikotinell TTC and others. They are also used in substitution therapy. The most optimal agent may choose a specialist considering the individual characteristics of the smoker.

Babies

Nicorette experience treating children and adolescents under 18 years of absence, so its use for children is not practiced.

With alcohol

In the treatment of undesirable Nicorette take alcohol and energy drinks.

During pregnancy and lactation

Today is not enough studied the negative impact of the drug on the fetus. There is evidence that the drug may have a negative effect on the respiratory and cardiovascular system of the fetus. Nicotine is able to cross the placenta, it is excreted in breast milk, so it may be dangerous to the fetus or child.

If you attempt to quit smoking without replacement therapy in pregnant women are unsuccessful, matched the expected benefits of the drug for the woman and the risk - to the fetus.

When feeding Nicotine may get into the milk, so take Nicorette nursing mother can not later than two hours before the start of feeding.

For more information about the drug delivers the official website: nicorette.ru or nicorette.ua.

Reviews of Nicorette

There are different opinions about treatment with this agent. But mostly reviews of Nicorette patch and reviews of chewing gum Nicorette positive, as many people this medication really helps to get rid of a bad habit. Judging by the majority of reviews, the ability to quit this habit of using Nicorette smoking experience depends. Smokers also note that a patch from smoking more convenient to use than tablets or chewing gum.

If you read the reviews of doctors gum from smoking, then they suggest that chewing gum helps a lot to reduce the number of cigarettes smoked per day.

However, those looking for detailed reviews about this medicinal product, mainly interested Nicorette patch helps you quit smoking?

Ex-smokers say that the first year of treatment to get rid of dependence Nicorette easier than treatment after the second return of Nicorette smoking habit. In most cases, the treatment of drug indicated a much smaller dependence on the desire to smoke.

People who post reviews, note that Nicorette patch reduces the attraction to smoking almost from the first day of use. It is important to clearly take into account contraindications, know how to choose the correct patch, and how to use them in the treatment process. Be sure to study the instruction, from which you can see how many pieces per pack patch can be where to glue the patch, can I smoke with the patch, etc.. Most important is the 1st stage of treatment, so in this period must be very strictly follow the instructions.

In the review, there are also some side effects, developing the treatment. It is a headache, redness of the skin in the field of using the patch, changes in appetite, and others. However, doctors say that most of the symptoms is connected with the rejection of cigarettes or a decrease in their number. In addition, people who used Nicorette note that drug treatment helps in the process of quitting smoking to maintain a normal weight.

Price Nicorette where to buy

Cost Nicorette gum   an average of 300 to 330 rubles. 30 pieces per pack. Gum implemented in Ukraine for about 80-120 USD.

How much is nicotine patch It depends on the place of its realization. The average price of Nicorette patch is from 600 to 650 rubles. 7 pieces per package. In Ukraine, the cost of the patch is 170-220 UAH. The price depends on the region. For example, in the Zaporozhye patch can be bought at the price of 200 USD. 7 pcs.

Tablets smoking   sold at an average price of 400 rubles per pack of 30 pieces.

Buy Nicorette Inhaler   It can be as low as 330 rubles. (in multiples of 18 inhalers and mouthpiece).

Sometimes it allows you to buy cheaper Nicorette action or sale.