Description overdue on 05/13/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Side effects
• Contraindications
• Instructions for use (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

The active ingredient of the drug Methotrexate is Vero Methotrexate . 1 ml of the drug may contain 5 or 10 mg of this material.

Product form

The drug is a solution for injection. The cardboard package may contain one or five glass vials of medicine.

Pharmacological action

Vero has Methotrexate antitumor effect .

Pharmacodynamics and pharmacokinetics

The drug belongs to the group antimetabolites . The mechanism of action is aimed at the restoration of an obstacle to an active dihydrofolate tetrahydrofolate. Exhibit enhanced activity against rapidly growing cells. In addition, it has a slight immunosuppressive effect .

Depending on the size of the received dose penetrate the BBB (marginally). Enters the system Krovostok intrathecal in large doses. The biotransformation in the liver. The output unchanged through the kidneys and the bile.

Indications

Vero Methotrexate is administered in these cases:

• trophoblastic disease ;
• kidney cancer ;
• lung cancer ;
• sharp Lymphocytic Leukemia ;
• squamous   neck cancer   and heads ;
• penile cancer ;
• germinogennye ovarian tumors   and eggs ;
• vulvar cancer   and   cervix ;
• retinoblastoma ;
• Ewing's sarcoma ;
• ureter cancer ;
• megakaryoblastoma ;
• cancer of the renal pelvis ;
• medulloblastoma ;
• psoreaz   (severe);
• mammary cancer ;
• osteosarcoma ;
• liver cancer ;
• myagkokletochnaya sarcoma ;
• skin cancer ;
• esophageal carcinoma ;
• rheumatoid arthritis (severe).

Side effects

There are side effects:

• anorexia . diarrhea . pharyngitis .   melena . ulcerative stomatitis . gingivitis . enteritis , Nausea, pancreatitis ; prolonged daily use may cause hepatic necrosis , Perilortalny liver fibrosis , Fat atrophy, cirrhosis ;
• thrombocytopenia . anemia .   leukopenia ;
• headache, fatigue, drowsiness, golovukruzheniya, convulsions, aphasia ;
• oligospermatism , Decreased libido, violation spermatogenesis   and oogenesis , Impotence, menstrual disorders;
• cystitis . hematuria , Renal dysfunction;
• hives , Fever, Stevens-Johnson syndrome, decreased immunity, epidermialny toxic necrolysis;
• pigmentation disorders, skin rashes, acne , Telangiectasia, furunculosis , Photosensitivity;
• eye irritation, conjunctivitis , Bleary eyes, cataract , Fear of light.

Contraindications

The appointment of the drug Vero Methotrexate is contraindicated in the following cases:

• thrombocytopenia ;
• immunodeficiency;
• impairment of renal function;
• leukopenia ;
• pregnancy;
• abnormal liver function.

Instructions for use (method and dosage)

The drug is taken orally, perhaps as intravenous and intramuscular injection, introlyumbalnoe (the spinal canal).

The size of the dose is chosen individually, depending on the stage of the disease, anticancer therapy and condition of the hematopoietic system.

Overdose

If symptoms of overdose oppression of the hematopoietic system .

As treatment is recommended calcium folinate , Which must be administered intramuscularly or intravenously. The dose of calcium folinate should be equal to or greater than the received dose methotrexate. Then you need to enter a few more doses until the level Methotrexate   in the blood reaches a level below 10-7 mol.

Hydration may be required if a large overdose to prevent precipitation of methotrexate or its metabolites in the renal tubules.

Cooperation

Preparations containing   folic acid As well as its derivatives reduce the effectiveness of methotrexate.

The toxic effects of methotrexate can be amplified with the concurrent use of penicillins   (including the extremely small doses).

Mielodepressivnoe action may increase in the combined use of methotrexate and sulfonamides   (especially with co-trimoxazole).

Weight mielodeprescia   and stomatitis may develop at reception Nitrogen oxide and Methotrexate .

Concentration valproic acid   in the blood may be reduced when it is used together with the drug.

This medication (even in very small doses), take after therapy tetracycline It can have a toxic effect. The same result can lead to the joint application NSAIDs .

Reduced levels of methotrexate in the blood possible while taking the drug at the same time kolestiraminom .

The absorption of methotrexate via the gastrointestinal tract is reduced due to the reception paromomycin   and neomycin.

Increase blood levels of methotrexate may welcome omepazola . By reducing the renal excretion matotreksata, its concentration may be increased to four times at the reception probenecid .

The risk of hepatotoxicity is increased in patients treated with retinoids, and the drug at the same time.

Synergy action likely if using fluorouracil   and methotrexate. If you enter before fluorouracil methotrexate toxicity of the latter may be reduced.

Increased toxicity is possible in those patients who have used cyclosporine   after methotrexate.

Increased toxicity of methotrexate can be caused by taking Cisplatin .

Terms of sale

The drug can be purchased at the pharmacy when a prescription.

Storage conditions

In the dark, not wet place. Temperature - up to 25 ° C.

Shelf life

Keep 3 years.

Cautions

Apply the drug should not be in: stomach ulcer . ulcerative colitis . ascites . duodenal ulcer . gout . pleural effusion . nephropathy .

With varicella   (including if it has been moved recently or had contact with those suffering), herpes Herpes   or other infectious diseases is not recommended to use the drug.

The picture of peripheral blood, chest X-ray, kidney and liver function need to be controlled as before treatment and during it.

Do not vaccinate patients and their family members.

It should be combined acetylsalicylic acid   and the medicine with caution.

During experimental studies found mutagenic   and carcinogenic   effects of methotrexate.

Analogs

By analogues of the drug can be attributed methotrexate-Teva . metodzhekt   and Methotrexate Ebewe .

During pregnancy and lactation

Receiving the drug during pregnancy is forbidden. If you want to take the drug should be stopped breast-feeding. During the reception, Vero methotrexate must use reliable contraception.

During experimental studies found teratogenic   and fetotoxic   effects of methotrexate.

Reviews

The drug should only be administered in doses prescribed by your doctor. Patients say the effectiveness of the drug.

Price, where to buy

The average cost of medication is 830 rubles.