Description overdue on 07/08/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Bonifen (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

The composition of one tablet included 275 mg naproxen sodium ; to excipients include povidone, MCC, magnesium stearate As well as talc, and purified water; film coating consists of colorant Opadry YS-1-4215 Consisting of the final mixture macrogol, titanium dioxide (E171) , and dye indigo carmine (E132) and hypromellose .

Product form

With film-coated tablets are packed in blisters of 10 pieces, which, together with recommendations on the application are placed in cardboard boxes.

Pharmacological action

Bonifen is a nonsteroidal anti-inflammatory drug which has antipyretic, analgesic and anti-inflammatory action.

Pharmacodynamics and pharmacokinetics

The mechanism of action is non-selective inhibition of COX-1 and COX-2.

Tablets containing 275 mg of   naproxen sodium , Dissolve easily and quickly absorbed from the gastrointestinal tract. This provides a rapid onset of analgesic effect.

Bioavailability reaches more than 95%, and receive the food does not influence on the rate and completeness of drug absorption. Time to reach Cmax is approximately 1-2 hours.

Naproxen sodium   It has a very strong connection to plasma proteins. It reaches more than 99%. Css is possible to determine approximately 2-3 day drug administration.

The process   metabolism naproxen sodium   It takes place in the liver to form dimethyl-naproxen and CYP2C9 enzyme group.

T1 / 2 is 12 to 15 hours.

The value of clearance - 0.13 ml / min / kg.

About 98% of the drug Bonifen excreted in the urine and the bile - about 0, 5-2, 5%.

In renal failure may occur cumulation metabolites .

Indications

It is recommended to use the drug "Bonifen" for the following types of pain:

• at headache (migraine) ;
• at s at bnoy pain ;
• at spinal neuralgia (torakalgii, sciatica, cervicalgia) ;
• at radicular pain ;
• at arthralgia ;
• at viral diseases ;
• at myalgia .
• at primary dysmenorrhea .

Contraindications

Do not use the drug "Bonifen":

• when expressed renal failure ;
• if you are hypersensitive naproxen sodium ;
• during exacerbation gastric ulcer or duodenal ulcer ;
• at tendency to Bleeding from the gastrointestinal tract ;
• the oppression bone marrow hematopoiesis ;
• at pregnancy and between   Lactation .

Also Bonifen absolutely can not be used in the treatment of children younger than 9 years old and \ or with a body weight not exceeding 27 kg.

Side effects

During treatment Bonifen patients may experience severe discomfort from the following side effects:

From the digestive system:

• from constipation . abdominal pain, dyspepsia, nausea, diarrhea, ulcerative stomatitis, erosive and ulcerative lesions of the gastrointestinal tract and bleeding, elevated liver enzymes, abnormal liver function, jaundice, bloody vomiting, melena.

CNS:

• from hearing loss, dizziness, headache, drowsiness, depression, sleep disorders, inability to concentrate, insomnia, malaise, myalgia and muscle weakness, slow the rate of reaction, aseptic meningitis, cognitive dysfunction.

For the skin:

• from pruritus, ecchymosis, increased sweating, purpura, alopecia, photodermatosis .

From the senses:

• from tinnitus, visual impairment, hearing impairment .

Cardio-vascular system:

• from swelling, shortness of breath, palpitations, congestive heart failure, vasculitis .

With the genitourinary system:

• from glomerulonephritis, hematuria, interstitial nephritis, nephrotic syndrome, renal failure, renal papillary necrosis, menstrual disorders.

From the side of hematopoiesis:

• from eosinophilia, granulocytopenia, leukopenia, thrombocytopenia, aplastic anemia.

The respiratory system:

• from eosinophilic pneumonitis .

Allergic reactions:

• from skin rash, urticaria, angioedema, epidermal necrosis, erythema multiforme, Stevens-Johnson syndrome.

Other:

• from thirst, hyperthermia, hyperglycemia, hypoglycemia, hemolytic anemia .

Instructions for use Bonifen (method and dosage)

In this manual, the number of tablets given for simple Bonifen, which contains 275 mg naproxen sodium . At reception Bonifen Forte Which contains 550 mg of naproxen sodium is necessary to reduce the number of pills to 2 times.

The tablets are taken orally, washing them down with a sufficient amount of liquid.

If the drug is used as a analgesic , The daily dose should not exceed 4 tablets. Optimal average dose of 550-1100 mg.

In very severe pain can take a loading dose - 2 tablets Bonifen. But the instructions for use (especially the section "Contraindications") in this case, the medication should be studied in detail. Allowed to take 6 tablets per day, ie. E. 1650 mg naproxen sodium But not more than 2 weeks.

If the drug Bonifen used as antipyretic, its initial dose is 2 tablets (550 mg), and further necessary to take 1 tablet (275 mg) every 6-8 hours.

To prevent attacks migraine   necessary to take 2 tablets (550 mg), 2 times per day. But treatment under the scheme must necessarily be terminated if for 4-6 weeks of drug seizures migraine   not decrease. Many doctors advise at the first sign of headache immediately take 3 tablets, t. E. 825 mg naproxen sodium And, if necessary, after 30 minutes, take 1-2 tablet formulation.

In order to relieve menstrual pain and cramps will suffice for the first time to take 2 tablets (550 mg), and further to reduce the dose twice and take 1 tablet (225 mg) every 6-8 hours.

In the case of an acute attack gout   the initial dose may be 3 tablets t. e 825 mg n a Proxenus sodium , Followed by 8:00 take 2 tablets later, and then every 8 hours to take 1 tablet complete cessation of attack.

With arthritis, osteoarthritis and ankylosing spondylitis   The first dose should be 2-4 tablets (550-1100 mg) in 2 divided doses (morning and evening).

Take 3 (825 mg) to 6 tablets (1650 mg) may Bonifen patients suffering from severe pain or nocturnal severe morning stiffness. Note that in this case the need for compulsory consultation with a physician who can change the dose depending on which symptoms predominate in the patient.

Children who have reached the age of 9 years and / or weight of their bodies for more than 27 kg Bonifen appoint 10 mg / kg in 2 divided doses per day.

Overdose

If overdose Bonifen patient may experience discomfort of the following symptoms:

• from sleepiness ;
• from dyspeptic disorders (heartburn, nausea and vomiting, abdominal pain) ;
• of total weakness ;
• from   tinnitus ;
• from irritability .

In severe cases, the patient may even suffer:

• from hematemesis ;
• from melena ;
• from disturbances of consciousness ;
• from seizures ;
• from renal insufficiency.

Treatment of overdoses is done as quickly as possible to gastric lavage   and spend symptomatic therapy   activated carbon, antacids, histamine H2 receptor . protonnovoy pump inhibitors . Please note that the dialysis in overdose Bonifen ineffective.

Cooperation

At simultaneous reception anticoagulants   with Bonifen should be remembered that   naproxen   significantly increases bleeding time.

Not recommended Bonifen with other NSAIDs, because it may cause the development of side effects.

Patients who are treated at the same time hydantoins, anticoagulants or other drugs binding to plasma proteins, it must be ensured that there was an overdose of these drugs.

Bonifen drug can decrease antihypertensive action propranolol And other   beta-blockers . The drug significantly increased risk renal failure   in the case of simultaneous application   ACE inhibitors .

Under the influence of Bonifen natriuretic effect furosemide   It can be inhibited.

Concentration lithium in plasma can be increased by inhibition of renal clearance.

A reception probenecid   could trigger an increase in the level of naproxen   in plasma.

Naproxen may cause slow excretion phenytoin, methotrexate and sulfonamides That can lead to their toxic effects.

Cyclosporine Reacts to naproxen , Provokes renal failure .

Antacids, which are composed of magnesium and aluminum Can greatly reduce the absorption naproxen .

Terms of sale

Bonifen approved for use as a drug without prescription.

Storage conditions

Bonifen should be stored in a dry place inaccessible to children at temperature not exceeding 25 degrees Celsius.

Shelf life

Bonifen stored 5 years if all conditions of storage.

Analogs

The main counterparts of the drug Bonifen are:

• Naproxen;
• Promax;
• Tsefekon.

Reviews Bonifen

Average rating Bonifen forums is 4, 3 to 5-point scale.

Ins   Visitors say the drug forums:

• quickly eliminates pain;
• It helps with cramps in the critical days;
• It gives the effect of a long;
• available without a prescription.

The disadvantages   Bonifen panellists are:

• a huge number of side effects;
• quite a high price;
• inefficiency.

Reviews of doctors from which tablets Bonifen save and why Bonifen Forte is more effective?

After analyzing the responses about Bonifen doctors, we can conclude that at the moment Bonifen is a very popular painkiller, which is capable of rapidly and permanently remove any pain.

Also, experts confirm the information that Bonifen Forte   It has higher potency and rapid effect, but not due to the fact that its structure has some additional substance, and because the tablets Bonifen Forte contains 2 times more naproxen sodium .

Price Bonifen where to buy

Bonifen average price in Ukraine is UAH 50. If you compare it to how much drug Bonifen Forte The difference between them is about 20 USD.

Tablets Bonifen in Moscow can be bought for 110 rubles.