Description overdue on 24.09.2011

International name of the drug - Ketorolac . It refers to a group NSAIDs . It has analgesic, anti-inflammatory and antipyretic effect is moderately expressed. The analgesic effect is comparable to morphine .

Dosage Form:

Coated tablets. Solution / m in / in.

Indications:

Pain: traumatic injuries, rheumatism, strains, sprains, sciatica, toothache, cancer, pain in the postoperative, postpartum.

Contraindications:

Ketanov prohibited from accepting patients with " aspirin triad ": Intolerance of drugs pyrazoline group   + bronchial asthma   + hay fever nasal   (relapsing course). Among the contraindications peptic ulcer   Gastrointestinal tract in the acute stage, pregnant, hypovolemia, liver failure, lactation, renal insufficiency, children under 16 years.

Precautions Ketanov used in patients with asthma, chronic heart failure, cholestasis, disorders of the renal system, active hepatitis, SLE ( systemic lupus erythematosus ), Sepsis, nasal polyps. Elderly persons over 65l. before applying the drug should consult a doctor.

Side effect:

Gastrointestinal tract : Diarrhea, dyspepsia, gastralgia, cholestatic jaundice, acute pancreatitis, hepatomegaly, ulcerative lesions of the stomach lining. The risk of complications is increased in patients older than 65 years.

The urinary system : Pain in the lumbar region, acute renal failure, hemolytic uremic syndrome, nephritis, frequent urination, kidney swelling.

Respiratory system : Rarely observed dyspnea, bronchospasm, laryngeal edema, rhinitis.

Senses : Hearing loss, vision, ringing in the ears.

Central nervous system : Dizziness, frequent headaches, increased sleepiness. In rare cases, there is depression, hallucinations Psychosis, hyperactivity, aseptic meningitis .

Cardiovascular system : High blood pressure, fainting, swelling of the lungs.

Forming Organs : Leukopenia, anemia, eosinophilia.

The system of hemostasis : Rectal, nasal, postoperative bleeding.

Skin : Rash, exfoliative dermatitis, urticaria.

Local reactions Pain, numbness, burning sensation at the injection site.

Perhaps the development of allergies, fever, edema.

Overdose:

Symptoms of overdose Ketanov: erosive gastritis , Dyspepsia, peptic ulcer, metabolic acidosis , Disruption of the renal system. Treatment includes gastric lavage, timely reception adsorbents, holding symptomatic treatment.

Special instructions:

Ketanov through 24-48ch. ceases to affect platelet aggregation . It is not recommended to use the drug on a background of hypovolemia in order to prevent the development of adverse reactions from the renal system. If necessary, the drug can be combined with drug analgesics . Course simultaneous reception paracetamol   should not exceed 5 days. The drug is not a means of sedation and is not used in obstetric practice for the purpose of pain relief. Ketanov causes drowsiness, headache, so you should refuse to perform work which requires high concentration of attention.

Drug Interactions:

Simultaneous treatment with drugs of the NSAID, ethanol . glucocorticosteroids   increases the risk of bleeding in the gastrointestinal tract. Paracetamol intensifies nephrotoxicity, methotrexate - hepatotoxicity. Probenecid increases the concentration and the T1 / 2 of ketorolac. To prevent bleeding is not recommended to combine Ketanov and thrombolytics, heparin , Antiplatelet agents, ceftazidime, pentoxifylline , Indirect anticoagulants. The drug reduces the effectiveness of diuretics, drugs that lower blood pressure. Antacids do not affect the degree and completeness of absorption of the drug. Ketanov increases hypoglycemic effects of insulin . At simultaneous reception sodium valproate   disrupts the aggregation of platelets. Increases concentration nifedipine . verapamil .