Description overdue on 17.10.2011

The main active substance acts Nimesulide It refers to the group NSAIDs   (artist sulfonanilides ). It has expressed pyretic . anti-inflammatory . analgesic   effects simultaneously. Mechanism of action of drugs based on the inhibition of synthesis of hormone-like substances - prostaglandins . The drug effectively blocks synthesis of them in the inflammation than in the kidney or gastrointestinal mucosa. Prolonged treatment is well tolerated. Nimesil rapidly absorbed in the body. The maximum concentration is reached after 1-2h. after receiving the drug. Effective 6-8ch.

Dosage Form:

Granules in sachets for preparation of suspension. Ingested orally.

Indications:

Ankylosing spondylitis . rheumatism . synovitis . osteoarthritis . tenosynovitis . tendinitis . bursitis , Pain in the algodismenoree After injury, fever in infectious, inflammatory diseases, myalgia . neuralgia Pain in the spine, traumatic inflammation of the musculoskeletal system, soft tissue damage.

Contraindications:

Bleeding from the gastrointestinal tract in the acute phase, pregnancy, severe functional impairment in the kidney, ulcerative lesions gastrointestinal, hypersensitivity, lactation.

Side effect:

In most cases, compliance with the recommendations drug is well tolerated, but in the first stage of treatment (either with increasing dose) can manifest a side effect of the drug. Central nervous system : Reye's syndrome ( encephalopathy ), Drowsiness, dizziness, migraine , Nightmares, nervousness, anxiety. Gastrointestinal tract : Dyspepsia, constipation . gastritis . flatulence , Bleeding, diarrhea, ulcers of the stomach wall mucosa, jaundice, cholestasis, hepatitis , Elevated liver enzymes. Respiratory : Bronchospasm, dyspnea. Cardiovascular system : Increased blood pressure, tachycardia, flushing, hemorrhage. Senses : Disorders of the visual analyzer. The urinary system : Urinary retention, renal failure, dysuria, oliguria, hematuria, interstitial nephritis.   Hematopoietic system : Purpura, pancytopenia, thrombocytopenia, eosinophilia, anemia.

Mode of application:

100 mg orally after meals twice a day. The contents of the sachet dissolve in a glass of water. Depending on severity of the disease drug dose can be increased. Older patients the dose is adjusted downward. Drugs are not recommended for use in pediatric patients.

Overdose:

Signs of overdose Nimesil: vomiting, drowsiness, apathy Nausea, gastrointestinal bleeding. No specific antidote nimesulide does not exist, treatment is symptomatic.

Special instructions:

Be wary appoint patients Nimesil old age, diseases cardiovascular system, kidney malfunctions, disorders of the upper gastrointestinal tract, in the background antiplatelet   and anticoagulant therapy . With the utmost care appoint patients with hypertension , Heart rhythm disturbances. The drug slows reactions. In its composition comprises sucrose, which is important and should be considered when administered to patients with pancreatic diseases, diabetes . Nimesil contraindicated in pregnancy, lactation.

Drug Interactions:

Nimesil increases the effectiveness of drugs that reduce blood clotting. Inhibitory effect furosemide . Enhances toxic effects Methotrexate , Nephrotoxicity cyclosporine . Increasing the concentration of lithium in the blood. At simultaneous reception sulfonamides . hydantoin   Nimes and the need to monitor the health status at short intervals.