Description overdue on 29.08.2011

Pentalgin is a combined anti-inflammatory . antipyretic   and analgesic   drug. In its composition it enters five active components, which and cause pharmacological properties of the given preparation. Metamizol   and paracetamol   - A non-steroidal anti-inflammatory agents having pronounced anti-inflammatory effect. They inhibit the synthesis of prostaglandins   by inhibiting the enzyme tsiklooksienazy .

Codeine   is a drug belonging to the group of drugs analgesics Having analgesic effect and reduces the excitability of the cough center. At therapeutic doses has no effect on the secretory activity of the bronchial tubes and does not inhibit the respiratory center. Large doses of codeine can develop drug dependence.

In its turn, caffeine   - Excellent stimulant of the central nervous system, enhances the action of paracetamol and metamizol sodium, prevents the development of collapse . Metamizole in the walls of bowel biotransformiroetsa. In the liver, metabolized and excreted by the kidneys as metabolites.

Paracetamol has a deep connection to plasma proteins. Its half-life period is from one to four hours. Phenobarbital   - An inducer of microsomal liver enzymes. The period of its launch - three - four days.

Indications:

Apply Pentalgin for the treatment of people with acute pain of various localization - migraine , Headaches, algodismenorei, myalgia, headache and toothache, arthralgia. Also the medicine is used in patients SARS   and flu To relieve muscle pain, inflammation, fever.

Mode of application:

Use the drug orally, the tablet should not be chewed or milled. Recommended Pentalgin drink plenty of water. The interval between doses of the drug should be equal to at least four hours. The attending physician must individually determine the dose and duration of treatment for each patient. Typically, adolescents and adults once prescribed one tablet. Five days - the maximum duration of treatment.

Side effects:

Pentalgin can cause such symptoms:

• loss of appetite, disturbance of digestion and stool, vomiting, nausea, dry mouth;
• excessive activity of liver enzymes;
• violation of sleep, tremor of the extremities , Irritability, headache;
• anemia, premature beats, high blood pressure;
• noise in the ears, increased intraocular pressure, violation of of view of;
• an allergic reaction: hives, angioedema , Rash, bronchospasm.

If you experience side effects, contact your doctor.

Contraindications:

The drug is contraindicated in patients who have individual intolerance, severe kidney disease, ulcerative lesions of the stomach, disorders of the circulatory system, myocardial infarction , Hypertension, arrhythmia.

Pentalgin forbidden to use to persons up to 12 years old, pregnant and lactating women. Also, it is not necessary to appoint to those who not so long ago suffered a head injury, prone to bronchospasm, suffer from diabetes, asthma.

Patients occupation that includes the management of complex mechanisms and machines have to be very vigilant.

Drug Interactions:

It was observed increase in the toxic effect when used in conjunction with Pentalgin nonsteroidal anti-inflammatory agents. Cimetidine   reduces paracetamol toxicity. Enhances the toxicity of of Metamizolum of sodium at a combination of with oral contraceptives, allopurinol . antidepressants .

Caffeine reduces the effectiveness of drugs that depress the nervous system and enhances the action of non-steroidal anti-inflammatory. It is impossible to use in conjunction with Pentalgin ethanol .