Description overdue on 30.10.2011

Combined preparation analgesics, antipyretics . The composition contains caffeine . paracetamol   and codeine . Caffeine increases alertness, reduces sleepiness, fatigue, increased heart rate, arterial hypotension, increases blood pressure. Caffeine increases the analgesic effect of the drug. Paracetamol has analgesic   and antipyretic effect . Codeine improves pain tolerance, has analgesic effect.

Indications:

Solpadein effectively relieves pain: ossalgia, migraine , Arthralgia, neuralgia , Headache, tuberculosis, radiculitis , Sinusitis, toothache, post-traumatic pain, sore throat, "the common cold" diseases, feverish syndrome.

Contraindications:

Panic, anxiety disorders,   agoraphobia Organic CVD (atherosclerosis, myocardial infarction   in the acute period) ventricular premature beats . paroxysmal tachycardia . bronchial asthma Cardio-pulmonary insufficiency, insomnia, hypertension, alcohol intoxication, epilepsy , Traumatic brain injury, hypocoagulation, anemia, toxic dyspepsia , Cranial hypertension, thrombocytopenia, severe pathology of hepatic, renal system, blood oppression, pregnancy. Precautions Solpadein prescribed for benign hyperbilirubinemia   (Dubin-Johnson syndrome, Gilbert), alcoholic liver disease, viral hepatitis, glaucoma , Tendency to seizures, irritability, old age. Solpadein not applied in paediatrics.

Side effect:

Dyspeptic disorder, leukopenia, stomachalgia , Agranulocytosis, increased liver transaminases, constipation . hemolytic anemia , Thrombocytopenia, tachycardia, allergic.

Mode of application:

A tablet is previously dissolved in a glass of water. Solpadein are inside at intervals of not less than 4 hours, 4 times a day 2 tablets. The day of not more than 8 tablets. Children 12-16 years old are encouraged to take on 1t. The day is not more than 4 tablets. The drug should not take more than 3 it to lower the temperature, and more than 5 days for pain.

Overdose:

Long-term use of the drug in high doses has hepatotoxic effects. Manifested dyspepsia, sweating, convulsions , Ringing in the ears, pale skin, drowsiness, bronchospasm . collapse , Confusion, difficulty breathing, tachycardia. Treatment is symptomatic. Specific antidote in overdose solpadein not.

Special instructions:

Solpadein prescribed with caution in diseases of the respiratory system (asthma), taking lipid-lowering, anti-emetic drugs, antidepressants. In the period of treatment to give up the use of tea, coffee with the aim of preventing the development of arrhythmia, tachycardia, insomnia, mental excitement. Long-term treatment requires regular monitoring of the blood. Is not compatible with alcohol since toxic effects on the liver. Not recommended for persons suffering from chronic alcoholism. Codeine can cause addictive . Solpadein causes drowsiness, reduces the rate of reaction.

Drug Interactions:

Prolonged use increases the effects Solpadein anticoagulants   (coumarin, warfarin), which may lead to bleeding. Phenytoin, carbamazepine Zidovudine, tricyclic antidepressants, phenylbutazone, rifampicin , Flumetsinol, barbiturates, phenytoin, ethanol and all inductors of microsomal oxidation increase the production of hydroxylated active metabolites, which can lead to severe intoxication, even a slight increase in dosage. Cimetidine   all inhibitors of microsomal oxidation reduce the severity of hepatotoxic effects of paracetamol. Domperidone   and metoclopramide   increase, and kolestiramin   reduces the rate of resorption of paracetamol. In the combination therapy reduces the effectiveness of Solpadin urikozuricheskih drugs. Caffeine spooben accelerate absorption ergotamine . Analgesics, hypnotics and sedatives have a more pronounced effect on contact with codeine. Under the influence of ethanol increases the half-life of paracetamol increases the hepatotoxic effects of the drug.