Description overdue on 04/06/2013

Non-narcotic analgesics . Combined preparation Tsitrapak has psychostimulant, antipyretic and analgesic effects. The medicines are the active ingredients ascorbic acid, paracetamol, caffeine, acetylsalicylic acid. Vitamin C   (ascorbic acid) has been actively involved in the regulation of oxidation-reduction reactions, tissue regeneration , Carbohydrate metabolism, in the process of synthesizing steroid hormones and blood coagulation .  Vitamin C can reduce the body's need for pantothenic acid, folic acid, vitamin A, E, B1, B2, reduces vascular permeability, improves the body's resistance to microorganisms .  If states, which are accompanied by fever, medication can satisfy the increased needs of the organism in ascorbic acid .  Aspirin inhibits platelet aggregation, has analgesic, antipyretic, anti-inflammatory effects, violates synthesize prostaglandin, inhibits the activity of cyclooxygenase 1 and 2, a non-steroidal anti-inflammatory active ingredient .  Caffeine can increase the concentration of analgesics in the central nervous system and increases efficiency (mental and physical), reduces the severity of fatigue and drowsiness, reduced aggregation platelet blood cells, expanding the lumen of blood vessels in the kidney, heart, skeletal muscle, brain, raises vasomotor center, increases the excitability of spinal reflex, the activity of the respiratory center. Paracetamol has a weakly expressed anti-inflammatory effect, has antipyretic and analgesic effects (inhibits synthesize prostaglandins, affects thermoregulation center). Tsitrapak available in tablet dosage form in the blister.

Indications:

Tablets are indicated for the relief of Tsitrapak pain diverse backgrounds, and mild to moderate intensity. Indications for use of the drug Tsitrapak: arthralgia , Migraine, neuralgia, toothache and headaches. The drug is prescribed for feverish against the backdrop of acute respiratory infections and colds.

Contraindications:

The drug is not prescribed for Hemophilia When concurrent therapy with non-steroidal drugs, portal hypertension , Hemorrhagic diathesis, gastrointestinal bleeding, when gipoprotrombinemii , Pregnancy, before surgery, breastfeeding, vitamin deficiency K, renal disease, children under the age of 15 because of a high risk of developing Reye's syndrome. The elderly, gout, severe liver disease Tsitrapak of pills prescribed with caution. Instructions for use of the drug is not recommended for Tsitrapak remedy for individual hypersensitivity to caffeine, acetylsalicylic acid and ascorbic acid, paracetamol.

Side effect:

Allergic responses in the form of skin rashes of various localization, currently treated bronchospasm , Angioedema. Digestive system:   nausea, appetite disorders, gastralgia, vomiting, erosive and ulcerative lesions and gastrointestinal bleeding, diarrhea syndrome, disorders of the renal and hepatic systems. Long-term therapy may result in the development of thrombocytopenia , Disturbances of vision, dizziness, tinnitus, headache, hypocoagulation , Bleeding.

Mode of application:

Tablets Tsitrapak appoint 2-3 times a day. The maximum permitted daily dose - 4 tablets, single - 2 tablets. Children from 6 years appoint half tablet 2-3 times a day. The drug can be administered no more than 5 days of analgesic purpose, and no more than 3 days - antipyretic. Tablets need to drink enough milk or water (not less than 100 ml). If necessary, may increase the duration of treatment and dose of medication after consulting the treating doctor.

Special instructions:

Tsitrapak not recommended for children under viral infection due to the high content of ascorbic acid, which can lead to Reye's syndrome   (manifested forming an acute form of encephalopathy, prolonged vomiting, enlargement of the liver). Long-term treatment Tsitrapakom requires regular observation of changes of the blood and liver. Part of the preparation, ascorbic acid slows down time clotting That must be considered before elective surgery. Patients with wheeze reactions to acetylsalicylic acid and salicylates Tsitrapak prescribed for special precautions. Aspirin in low doses reduces the excretion of uric acid (may increase gout). The risk of developing hepatotoxicity   and digestive bleeding increases upon receipt of ethanol. Aspirin exerts teratogenecity   the fetus (slowing of labor, closes the ductus arteriosus in the fetus is formed hyperplasia vessels in the lung tissue, diagnosed hypertension in the blood vessels of the pulmonary circulation). The active components of the drug are excreted in breast milk, that can lead to dysfunction of platelets and of bleeding.

Drug Interactions:

Tsitrapak able to increase the effects of steroid hormones, anticoagulants , Heparin, hypoglycemic medications, reserpine. The drug reduces the effectiveness protivopodagricakih and antihypertensive drugs, furosemide, spironaloktona and other drugs that promote excretion Uric acid . Tsitrapak not recommended for use with rifampicin, AZT, ethanol, antiepileptic drugs, barbiturates because of the increasing severity of hepatotoxic effects. The drug increases the side effects Methotrexate , Sulfonylureas, other non-steroidal drugs.