Description overdue on 09.11.2011

Provides antipyretic and analgesic effect. Flamidez in its composition contains paracetamol . serratiopeptidase   and diclofenac . Paracetamol   It affects the thermoregulatory center of the hypothalamus to inhibit the production of prostaglandins , Thereby achieving analgesic   and antipyretic effect   drug. Serratiopeptidase is a proteolytic enzyme isolated from Serratia E55 - intestinal non-pathogenic bacteria. It has anti-edema, fibrinolytic and anti-inflammatory effect. Pain relief is achieved by blocking the production of pain amines from inflamed areas. Serratiopeptidase binds to alpha macroglobulin blood in a ratio of 1: 1. Through this enzymatic activity is retained antigenicity and masked. Serratiopeptidase (STF) gradually penetrates into the center of inflammation. Gidroliziruya bradykinin . Serotonin   and histamine   STP reduces the dilation of the capillaries, controlling the permeability. STP blocks inhibitors of plasmin by activating fibrinolysis plasmin. Diclofenac has antirheumatic, antipyretic, antiaggregatory, analgesic and anti-inflammatory action. Inhibits platelet aggregation, slows the rate of proteoglycan biosynthesis in cartilage. Flamidez recommended to appoint all pathological conditions involving edema .

Indications:

Flamidez prescribed for the relief of pain: post-operative, post-traumatic pain, rheumatoid arthritis , Arthralgia, myalgia, osteoarthritis, sinusitis, gynecological diseases, periodontal abscess, epididymitis, cystitis , Infectious diseases of upper respiratory tract.

Contraindications:

Ulcerative lesions of the gastrointestinal tract, blood formation disorders of unknown etiology, destructive inflammatory gastrointestinal diseases, asthma (acetylsalicylic), pregnancy.

Side effect:

GIT: dyspepsia, flatulence . anorexia , Violation of the chair, gastropathy   against the backdrop of NSAIDs, disruption of renal, hepatic system, increased liver transaminases, interstitial nephritis , Drug-induced hepatitis. Nervous system: insomnia, agitation, dizziness, fatigue, irritability . Arterial hypertension, thrombocytopenia, seizures, bronchospasm , Erythroderma, allergies.

Mode of application:

Flamidez is available in tablet form for oral administration, washing down the necessary quantity of water. Adults: three times a day for one tablet. Children: twice daily 1 tablet. The analgesic effect was observed after 2 hours and lasts up to 6h. The day may not acquire more than three tablets. The course of treatment depends on the severity of the disease, the individual patient.

Overdose:

Anorexia, dyspepsia, pale skin, nausea, disruption of renal and hepatic systems, vertigo. Requires the introduction of adsorbents , Gastric lavage. No antidote.

Special instructions:

Flamidez prescribed with caution in dyspeptic disorders, in renal, hepatic systems, diseases of the gastrointestinal tract after surgery, with porphyria , Congestive heart failure, asthma, the elderly. Flamidez reduces the speed of psychomotor reactions, affect the driving of vehicles.

Drug Interactions:

Part of the drug acetaminophen increases the effects of coumarin derivatives ( anticoagulants ) Increases the hepatotoxicity of other drugs. Kolestiramin   reduce and metoclopramide   increases the rate of absorption of paracetamol. At simultaneous reception of ethanol increases the hepatotoxic effects. Barbiturates   antipirichesky reduce the effect of paracetamol. Efficiency is enhanced under the influence of coagulants serratiopeptidase. Diclofenac increases Digoxin , Lithium, oral antidiabetic drugs, quinolone derivatives. Increases the risk of gastrointestinal bleeding, hyperkalemia when taking corticosteroids and diuretics. Diclofenac increases the toxicity of cyclosporine   and Methotrexate .