Description overdue on 09/14/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Nimid, instructions for use (method and dosage)
• Overdose
• Cautions
• Cooperation
• During pregnancy (and lactation)
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• With alcohol
• Reviews
• Price, where to buy

Composition

Sachets   It contains an active component - Nimesulide   and optional ingredients: Povidone K-30, tabletozu 80, Aerosil 200, sodium saccharin, flavor, citric acid monohydrate.

Preparation of suspension   It includes in its membership Nimesulide   and auxiliary substance.

Gel Nimid   It consists of an active substance Nimesulide and auxiliary components: carbomer 940, propylene glycol, disodium edetate, propylparaben, methylparaben, sodium gidroskida, purified water and flavorings.

Product form

The drug comes in the form suspension Placed in a vial of 60 ml, granules sachets   2g (100 mg) in 30 sachets packaging and gel form . The gel was placed in the tube 20 g, 30 g or 100 g

Pharmacological action

Each form of the drug has a non-steroidal, anti-inflammatory and   anesthetic   action.

Pharmacodynamics and pharmacokinetics

Active component Nimida - Nimesulide   -   It is NSAIDs Belonging to the group sulfonanilides . This ensures the drug analgesic, antipyretic and anti-inflammatory effects. Furthermore, Nimid prevents destruction of cartilage and proteoglycans, is capable of blocking pain impulses along the nociceptive system. This was a slight effect on COX-1 and gastric mucosa.

Also for this drug is characterized by antioxidant effect , Decrease in aggregation   Platelet and a decrease in bronchospasm .   which may provoke acetaldehyde and histamine.

Preparations for internal reception quickly and efficiently absorbed from the gastrointestinal tract. Reduce the rate of absorption of nimesulide could simultaneous use of food does not affect the plasma concentration of the substance. After 1, 5-3 hours after taking the drug in blood plasma forms a maximal concentration of nimesulide. Established that Nimid has high binding to plasma proteins. This medication is excellent and overcomes the blood-brain barrier. Particularly high concentrations of active substances are found in synovial fluid and inflammatory sites.

Metabolism It occurs in the liver, deducing of in an invariable the form of and in the active metabolite   It is carried out mainly   using kidney   and a small part - with the feces. The average period of removal of nimesulide is 3-5 hours.

When local use on skin Nimida marked a slight absorption of nimesulide in the general circulation. After the application is its slow penetration in the subcutaneous layer of fat, muscle tissue, joint capsule, or synovial fluid. Especially high concentrations of the drug are also formed in the hearth of inflammation.

Indications

A preparation in the form of granules and suspensions   prescribed for:

• symptomatic treatment of pain syndromes, diseases of bones, muscles or joints, for example - osteoarthritis, rheumatoid arthritis, bursitis, tendenite, myalgia ;
• the need for analgesics due to post-operative and post-traumatic pain, pain caused by diseases of upper respiratory tract, gynecological and dental pain;
• Fevers During the illness of upper respiratory tract and upper respiratory tract, as antipyretic.

Nimid gel   applied topically in cases of:

• degenerative and inflammatory of defeats the oporno-impellent device, with strong painful sensations and edematous, for example: arthritis, Bechterew's disease, osteoarthrosis, Reiter's syndrome, tendonitis, myositis, tenosynovitis, myalgia, osteochondrosis, neuralgia   and so on;
• inflammation of soft tissues caused by injuries as fractures and ligament injuries, bruises and muscle sprains.

Contraindications

The suspension and granules   Nimid not prescribed for:

• peptic ulcer 12 duodenal ulcer and stomach during the exacerbation of the liver or liver disease, hepatotoxic drug reactions in history, severe renal dysfunction, and so on;
  the joint the treatment of potentially hepatotoxic preparations;
• risk of bleeding;
• congestive heart failure;
• sensitivity to the components;
• pregnancy and   lactation;
• the age of 12;
• chronic alcoholism or drug addiction;
• fever and Flu ;
• suspected acute surgical deviation.

Ointment   is contraindicated in patients:

• have hypersensitivity to its components;
• from   dermatitis, infections   and skin lesions   in places application;
• from asthma Which causes the ASA;
• under the age of 12 years;
• at lactation, pregnancy .

Side effects

Patients who take powder   Nimid during treatment can experience:

• nausea, abdominal pain, constipation, diarrhea, and other abnormalities in the activity of the gastrointestinal tract;
• itching, skin rash, urticaria, angioedema,
• drowsiness, dizziness, headache.

Treatment with a suspension   can lead to the development of:

• skin rash, erythema, itching, sweating, dermatitis;
• disorders and pain gastralgia, constipation, nausea, diarrhea;
• jaundice, cholestasis , Changes of transaminase activity;
• drowsiness, headaches and dizziness;
• nervousness, anxiety, nightmares;
• edema, hematuria, urinary problems;
• hypertension, tachycardia   and so on.

Topical application of the gel may lead to flaking, itching, hives or anaphylactic reactions, which mostly occur in patients with hypersensitivity to ASA.

Nimid, instructions for use (method and dosage)

Nimid in the form of a suspension recommended for after meal . This dose and duration of treatment is determined by your doctor. Usually, the given form of the drug appoint for adult patients on the 100 mg 2 times per day. The maximum daily dose is 400 mg. For children of 12 years assigned to receive the drug two times a day in the calculation of 1, 5 mg per kg body weight. The maximum daily dose should not exceed 5 mg per kg of body weight per day.

Powder   Nimid, instructions for use recommends taking after meal   100 mg or 1 sachet twice a day . Thus pellets sachet carefully dissolved   200 ml of warm water. Apply powder or granules 2g should not be longer than the period prescribed by the attending physician.

Gel Nimid instructions apply Application Tips thin layer   on the affected cutaneous surface. At the same time you need to use a small amount of   facilities. Apply the gel is not more than 4 times per day to the area, which is most pronounced pain syndrome.

Overdose

Cases of overdose granules or a suspension   may manifest by symptoms such as: drowsiness, nausea, vomiting, lethargy, epigastric pain, high blood pressure, lethargy, bleeding, respiratory failure, renal failure, anaphylactoid reactions   and even coma. Thus symptomatic treatment. Is allowed gastric lavage, appoint chelators   or osmotic laxatives.

Cases of overdose gel Nimid   topical use not set .

Additional information

At the time of treatment is recommended to take Nimid minimum dosage That can be effective in a short duration of therapy.

The development of signs and symptoms of GI bleeding, liver dysfunction, such as vomiting, nausea, abdominal pain, anorexia, discoloration of urine, fatigue, and laboratory confirmation of liver function tests that indicate her injuries requiring immediate discontinuation of the drug.

It is also necessary discontinue treatment   Nimidom if patients appeared signs of worsening of renal function   or flu-like symptoms with fever.

Permanent medical supervision is required in the treatment of status of elderly patients and patients with hemorrhagic diathesis, as H imesulid   can influence the activity of platelets.

With care prescribe Nemidom patients with different pathologies of the gastrointestinal tract in history, such as Crohn's disease or ulcerative colitis.

Cooperation

The simultaneous use of suspensions and granules with Nimid   warfarin, acetylsalicylic acid   and some anticoagulants   often contributes to the development bleeding . Also, caution is required when co-administered of furosemide   patients suffering from disorders of the heart and kidneys.

As is known, means of group NPVS can lower CLEARANCE lithium, boosting its concentration in composition plasma blood and increasing toxicity substance. Therefore, it is necessary to monitor the concentration of lithium, if taken at the same time Nimid drugs and lithium.

There was no significant drug interactions when co-administered this drug and Theophylline, digoxin,   Ranitidine, glibenclamide a   and   antacids .

Simultaneous use of the gel Nimid and preparations of NSAIDs can sometimes cause local irritation: peeling, redness, hives. Strengthening anti-inflammatory effect of the gel contribute antirheumatic drugs   and   glucocorticoids .

Nimid during pregnancy

Contraindicated use of the drug in pregnancy   and Lactation . It was established that Nimesulide is able to exercise significant influence on fertility, so it is not recommended for women during pregnancy planning . Also noted inhibition of prostaglandin synthesis, causes pulmonary hypertension , Imperforate premature ductus arteriosus, hypamnion   and oliguria. Use of the drug increases the risk of internal bleeding, peripheral edema, and the weakening of labor function.

Terms of sale

The drug prescription.

Storage conditions

All forms of the drug should be stored in a cool and dark place. The gel does not need to freeze. Keep away from children.

Shelf life

Gel Nimid - 2 years, and the powder slurry - 3 years.

Analogs

The main counterparts of this drug include: Nimegesik, Nimesulide, Nise, Mesulid, Nimesil, Nimid forte.

Alcohol

During treatment Nimidom contraindicated use of alcohol Because such a combination may result to serious side effects .

Reviews Nimide

As the reviews of Nimide, it is actively used in a variety of cases. At the same time some patients celebrate its high efficiency, but this is mainly depends on the features of an organism and correctness of the destination of treatment.

Quite often patients take the given preparation, when you need to get rid of a tooth-, of menstrual and of traumatic pain, do not even suspecting, from what in fact he helps. Most users report that they begin to use this tool on their own, without referring to your doctor.

Thus, despite the fact that usually manifests after taking Nimida rapid analgesic effect, this treatment does not help to get rid of the basic problem of pain. Therefore, if the pain resumes, it is necessary to see a specialist.

Price Nimida where to buy

Cost gel Designed for outdoor use, in a tube of 30 g is placed within 159-175 rubles.

Price in Nimida   granules or a suspension   It is 557-620 rubles.