Description overdue on 01.04.2013

Non-steroidal, anti-inflammatory agent . The drug inhibits the activity of cyclooxygenase indiscriminately 1 and 2, which are actively involved in the regulation of the synthesis of prostaglandins (cause swelling and pain form). Tablets Trombopol have analgesic, anti-inflammatory, zharononizhayuschim effects. The active component acts acetylsalicylic acid . The decrease of prostaglandins in heat regulating center   It causes decline in body temperature due to the enhanced sweating and vasodilatation of the skin. As a result of the central and peripheral effects of the main component of the analgesic effect is achieved. The drug reduces the activity thrombotic events   by inhibiting synthesis of thromboxane A2 in blood platelet cells. Preparation retards adhesion and aggregation of platelets. Achieved with the help of the drug Trombopol (single dose) antiplatelet effect   stored 7 days. In patients with unstable angina, the drug reduced the risk of myocardial infarction, mortality.

The drug is used for primary and secondary prevention of myocardial infarction. The daily dose of 6 grams of the drug increases the prothrombin time, inhibits the process of synthesizing prothrombin in the liver tissue. Under the action of acetylsalicylic acid reduces the concentration of coagulation factors (2, 7, 9, 10), increased fibrinolytic activity of plasma. During the surgery the drug increases the rate of hemorrhagic complications increases the likelihood of bleeding. The drug stimulates the excretion Trombopol Uric acid   (disrupted process of reabsorption of uric acid in the kidneys). The drug is available in tablet dosage form (Effervescent Enteric-coated).

Indications:

The drug is prescribed for relief pain   (poorly defined, Moderate) of different origin: a toothache, migraine headache, neuralgia , Tuberculosis, radicular syndrome, lumbago, myalgia, arthralgia, headache at alcohol withdrawal syndrome . The drug used in feverish syndrome   against the background of infectious and inflammatory diseases.

Contraindications:

Instructions for use of the drug is not recommended for Trombopol medication intolerance of acetylsalicylic acid, hemorrhagic diathesis , Gastrointestinal bleeding, in patients with erosive and ulcerative changes in the digestive system in the acute phase, bronchial asthma (a form of induced intake of salicylates and preparations of NSAIDs), with concurrent therapy Methotrexate   a weekly dosage of 15 or more. Tablets Trombopol not prescribed for carrying a pregnancy, breastfeeding. The drug is contraindicated in children.

Side effect:

Trombopol medicine can cause nausea, Reye's syndrome   (development of liver failure in conjunction with rapidly progressive acute steatosis   and related encephalopathy), allergic responses (as bronchospasm angioedema   and skin rashes), diarrhea, anemia, thrombocytopenia , Gastralgia, anorexia, leukopenia. Long-term therapy can cause headaches, dizziness, bleeding, anticoagulation, erosive and ulcerative lesions of the digestive system, vomiting, bronchospasm, tinnitus, reduced visual auditory perception, interstitial nephritis , Disorders of vision, swelling, strengthen the symptoms of CHF, aseptic meningitis , Nephrotic syndrome, acute renal failure, papillary necrosis, pre-renal azotemia, together with hypercalcemia and hypercreatininemia, elevated liver enzymes.

Mode of application:

Trombopol taken orally. Anti-inflammatory and analgesic effects have a dose in excess of 400-500 mg. When pain and fever syndrome appoint 0, 5-1 grams per day (3 admission). The course of therapy should not exceed more than 2 weeks. Job for effervescent dosage forms of the medicament is 0, 25-1 gram (3-4 hours per day).

Special instructions:

Responses to the drug Trombopol show high performance medicine. The course of treatment with acetylsalicylic acid to achieve analgesic effect without consulting the physician should not exceed 5 days. Trombopol not prescribed for   infectious-allergic myocarditis , Rheumatoid arthritis, rheumatism, and pericarditis Rheumatic chorea . The drug is cancel 5-7 days before a possible surgical intervention. Long-term therapy requires mandatory fecal occult blood test and control blood parameters. Children welcome Trombopola can cause Reye's syndrome (an increase in size of the liver, development of acute encephalopathy period, prolonged, uncontrollable vomiting).

Concurrent therapy medicaments which neutralize gastric acidity, can significantly reduce the irritant effect of acetylsalicylic acid on the mucosal wall of the digestive system. For Trombopola characteristic teratogenecity   (premature closure of the ductus arteriosus, the splitting of the upper sky and other changes in the development of the fetus). In patients suffering from gout, the drug can cause an acute attack since reducing uric acid excretion in patients receiving aspirin. It requires full refusal of admission alcoholic beverages during the treatment period. Analogs of the drug Trombopol: cardiomagnil , TromboASS, atsekardol . The price of the drug Trombopol is 50-100 rubles depending on the pharmacy network.

Drug Interactions:

Trombopol can increase toxic effects Methotrexate , Reduce its   renal clearance . The drug increases the effects of heparin, narcotic analgesics, anticoagulants , Hypoglycemic agents, antiplatelet agents, thrombolytics , Sulfonamides. Aspirin reduces the effectiveness of drugs dirueticheskih (furosemide, spironalokton), antihypertensives, uricosuric medications (sulfinpirazona, benzbromaron). Ethanol-containing preparations, self ethanol glucocorticosteroids   enhance the damaging effects of medication on the mucous wall of the digestive tract, which can cause gastrointestinal bleeding. Trombopol increases barbiturates, digoxin and lithium salts in the blood. Absorption is reduced when treating both antacids . Myelotoxic drugs enhance the effect of haematological Trombopola.