Description overdue on 31.10.2011

The antimicrobial agent. Main, an active substance is a derivative of 8-hydroxyquinoline. Nitroxoline has a broad spectrum of bacterial exposure. The mechanism of action Nitroxoline directed to inhibition of DNA synthesis bacteria, the formation of specific complexes with metal-microbe cell enzymes. The drug inhibits the gram-positive flora, beta-hemolytic streptococcus . Gonorrhoea . mushrooms   (Candida, molds, dermatophytes, agents of the deep fungal infections ). Available in tablet form for 0, 05 g (10 or 50 pieces).

Indications:

Nitroxoline prescribed for infection of the urinary tract:   urethritis . cystitis Infected with BPH, prostate carcinoma, pyelonephritis . The drug is used to prevent infectious complications of diagnostic and therapeutic interventions character (cystoscopy, catheterization, surgical treatment of the kidneys).

Contraindications:

Polyneuritis , Kidney failure, cataract , Neuritis, anuria . oliguria , Liver failure, allergy. Nitroxoline not indicated during pregnancy, do not use in pediatrics.

Side effect:

GIT: dyspepsia, vomiting. Nervous system: paresthesia , Dizziness, headaches, polyneuropathy . In rare cases, there subacute mieloopticheskaya neuropathy . Manifested by diarrhea, epigastric pain, and then develops optic atrophy   and severe peripheral polyneuritis. Sometimes joins retrograde amnesia , Confusion. Tachycardia, elevated transaminase levels, allergies.

Mode of application:

Nitroxoline taken one hour before meals, washed down with the required amount of liquid. Prevent violations of the treatment regimen, these dosages during the entire course of therapy Nitroxoline. The course of treatment lasts 3 weeks: 100 mg 4 times daily.

Special instructions:

During the reception Nitroxoline feces and urine may take on a yellowish, saffron hue.

Drug Interactions:

Nitroxoline reduces absorption nalidixic acid . Simultaneous reception antacids , A part of which contains magnesium, reduces the effectiveness of the drug Nitroxoline.