Description overdue on 14-01-2012

Highly selective alpha-blockers . Adrenergic receptors in the body are mainly in smooth muscle tissue prostate , Smooth muscle Bladder   (in the neck) and smooth muscle tissue urethra   (in the prostatic portion thereof). The active ingredient of the drug Omnic - tamsulosin hydrochloride . By binding to alpha 1-adrenergic receptors on smooth muscle wall of the above, tamsulosin violates their interaction with mediator adrenaline . As a consequence, reduced muscle tone of the prostate, the bladder muscle and the urethral muscle tissue. This reduces the degree of obstruction, reduced dizuricheskih manifestations   in patients with prostatic hyperplasia (benign nature). On the smooth muscles of the vascular wall tamsulosin does not have a similar effect. This is explained by the fact that vascular cells have on their surface alfa1B adrenoreceptors and tropism tamsulosin thereto 20 times inferior to its receptor tropism alpha2a, which are predominantly in the urogenital system. In this way possible to achieve a high selectivity of action on these organs and tissues and to avoid the reduction of blood pressure in patients with normal pressure.

Indications:

Omnic (tamsulosin hydrochloride) has been widely used in therapy in Urology benign prostatic hyperplasia Accompanied by dysuric disorders .

Contraindications:

Tamsulosin hydrochloride is contraindicated in patients who have a history of present cases severe hypotension Including orthostatic character. Use caution in patients with chronic renal failure . The same is true with respect to patients who have the severe disorders of the liver parenchyma. If hypersensitivity to existing components of Omnic is contraindicated.

Side effect:

While taking tamsulosin may lower blood pressure, including orthostatic, compensatory palpitations. Nervous system   can respond to the reception of Omnicom dizziness, insomnia (can daytime sleepiness and nighttime insomnia) and general weakness. FROM of the urogenital system   there may be side effects such as the retrograde ejaculation , We can not exclude some decline libido . When an allergy to tamsulosin may occur itching , Rash. Digestive system:   frustration of a chair (as diarrhea And constipation ), nausea, vomiting.

Mode of application:

Issued Omnic capsules (one capsule contains 400 micrograms tamsulosin) modified release. This means that the drug enters the bloodstream from the intestine immediately, but gradually, so that over a period of 24 hours in the blood is maintained constant therapeutic concentration of tamsulosin. This feature allows one to take Omnic times per day (this is preferably done in the morning after a meal). The daily dose - 400 micrograms per day.

Special instructions:

During the course of therapy Omnicom need to be especially careful when you perform operations requiring fast psychomotor reactions and limit concentration. Before starting treatment with tamsulosin is necessary to ascertain the nature of benign prostatic hyperplasia. When tamsulosin may occur episodes orthostatic blood pressure reduction . In this case, we can recommend the patient to sit or take a few minutes a horizontal position until symptoms disappear, then you can slowly go up and go back to business as usual. In overdose recorded drop in blood pressure, and the most effective measure may be a simple translation of the patient in a horizontal position. Thereafter, it is recommended to wash out the stomach and give the patient sorbents. In severe cases, you can carry out activities aimed at increasing the volume of circulating blood (intravenous infusion of sodium chloride or other isotonic solution).

Drug Interactions:

Co-administration of the drug and Omnic cimetidine   entails an increase in the concentration of tamsulosin in blood. The opposite effect is observed with concomitant administration of furosemide, however, under the above combinations, the drug dosage adjustment is not necessary to produce Omnic. Warfarin when taken with Omnicom accelerates the elimination of tamsulosin. Diclofenac sodium   indirect anticoagulants   It has a similar effect. If Omnic administered in combination with other alpha1-blockers, there may be severe hypotension. The same effect can cause intake of alcohol during treatment with Omnicom. But in combination with tamsulosin antihypertensives such as the enalapril . atenolol   and nifedipine   the effect of potentiation of the hypotensive action is absent. Omnic no influence on the metabolism of diazepam, salbutamol, amitriptyline . propranolol , Glibenclamide, trichloromethiazide, chlormadinone finasteride.