Description overdue on 02/12/2014

Urological means.   Active ingredient - tolterodin . The drug improves urodynamics . The active agent is a muscarinic receptor blocker, and deystvyet targeted against the bladder muscles. Under the influence of the drug decreases the average volume of urine, eliminates incontinence and decreased frequency of urination. The active ingredient does not affect the QT interval.

The marked effect of the drug Urotol manifested by the end of the 4th week of therapy. Tolterodin well absorbed in the digestive system, the peak plasma concentration recorded in 1-3 hours. Active component metabolized to the main metabolite and a few non-active substances that are excreted by the kidneys. In patients with severe hepatic pathology system, observed increase in plasma neizmenenennogo tolterodina. With kidney disease   increased half-life tolterodina. The drug is available in tablet form, in blister packs of 14 pieces. Buy Urotol can be a pharmacy by presenting the prescription form.

Indications:

Urotol drug prescribed to patients who suffer multiple imperative urge to urinate. The drug is used for highly active bladder , Incontinence.

Contraindications:

The drug is not prescribed Urotol intolerance tolterodina at urinary retention , Severe course of ulcerative colitis, angle-closure glaucoma, toxic megacolon. In pediatric practice do not prescribe medication Urotol. Instructions for applying are encouraged to use caution when tolterodin neuropathy , Diseases of the kidney and liver, with reduced intestinal peristalsis, as well as patients at high risk for Myasthenia gravis ("Muscle impotence"). When treating patients who receive antiarrhythmics, check long QT interval, it requires special care. It is unacceptable during treatment to drive vehicles and other dangerous machinery.

Side effect:

Reviews on Urotol indicate a good tolerability of the drug. Common adverse reactions:   decreased lacrimation,   dyspepsia Dry mouth. Less commonly observed fatigue and impaired memory. Central nervous system:   change of accommodation, severe disorientation . vertigo , Confusion, disturbance of vision, increased drowsiness, headaches, hallucinations. Digestive system:   amplified flatulence, epigastric pain, constipation (due to lower intestinal motility ), Gastroesophageal reflux disease, dry mouth. Rarely recorded weight gain and the development of diarrheal syndrome. Changes in the heart and vascular system:   feeling heart palpitations, flushing of the upper body and face, and tachycardia. Some patients experience an allergic responses in the form of dermatitis, urticaria. Rarely develop angioedema, and anaphylactoid reactions. Rarely aggravated symptoms dementia Are registered chest pain, pain during urination, dry skin, exacerbation of chronic bronchitis, edema, urinary retention.

Overdose:

When receiving a one-time 12, 8 mg tolterodina registered pain urination, broken accommodation . Symptoms of overdose:   mydriasis, respiratory failure, tachycardia, cramps, nervous and emotional arousal, urinary retention, hallucinations. Antidote is not developed. Enterosorbents recommended intake, gastric lavage, holding symptomatic treatment. With the development of hallucinations, overstimulation and other central anticholinergic effects applied physostigmine . When seizures are administered benzodiazepines. When tachycardia and respiratory changes carried out measures to restore breathing and use of beta-blockers. With the development of mydriasis in patients receiving high doses Urotol prescribe eye drops to pilocarpine . During prolonged urinary retention catheterization performed.

Mode of application:

Tablets Urotol take entire inside. Invalid dose selection by dividing the tablets. The drug can be administered independently from the meal. The duration of therapy is determined by the attending physician only. Incontinence, bladder highly active   administered 2 mg twice a day. When poor tolerability tolterodina circuit can be changed: 1 mg twice daily. In kidney and hepatic system, when receiving strong inhibitors CYP-3A4, the daily dose is reduced to 2 mg. Medicine Urotol recommended to take 6 months. If you want to receive tolterodina can be continued after six months.

Special instructions:

Price Urotola depends on the pharmacy chain and an average of 350-500 rubles. The drug is not intended for the treatment of pregnant women and is contraindicated during breast-feeding. Before prescribing medication to exclude organic changes that could lead to the urgent need to urinate. Efficacy and safety of tolterodina in children has not been studied. Women are advised to use reliable methods of contraception for the duration of therapy with Urotol. The medicament may interfere accommodation of speed and psychomotor reactions, which limits its application in the control of complex machinery, vehicles.   Analogs Urotola:   Detruzitol, Tolterodine, Debye-.

Drug Interactions:

Medicines, anticholinergic effects, enhance the effect of Urotola and increase the risk of adverse and side effects. Tolterodin reduces the effectiveness of prokinetic. Muscarinic receptor agonists slow the action of the drug. Inadmissible simultaneous treatment of antifungals (itraconazole, ketoconazole, miconazole), and macrolide antibiotics (clarithromycin, erythromycin). Clinically significant pharmacological interaction in concurrent therapy with warfarin and oral contraceptives have been reported.