Description overdue on 09/18/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions on Maltofer (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

In one milliliter oral drops   contains 50 mg of the complex polymaltose ferric iron gidroskida   + Sodium propyl parahydroxybenzoate, water, cream flavor, methyl parahydroxybenzoate, sodium hydroxide, sucrose. In terms of hardware, one drop of the solution is 2, 5 mg.

Syrup Maltofer   (1 ml) contains 10 mg polymaltose iron complex   + Excipients (propyl parahydroxybenzoate, sorbitol solution 70%, water, cream flavor, methyl parahydroxybenzoate, sodium hydroxide, 96% ethanol, sucrose).

One tablet means   It comprises: gland   100 mg + additional ingredients (vanilla, talc, chocolate flavoring, microcellulose, dextrates, sodium cyclamate, macrogol 6000, cocoa powder).

Per ml solution oral   accounting for 20 mg gland   (in shape polymaltose complex of ferric hydroxide ) + Excipients (propyl parahydroxybenzoate, sodium sorbitol 70% solution of sucrose, methyl parahydroxybenzoate, sodium hydroxide, water, flavoring).

One ml solution for the / m   contains from 141 to 182 mg hydroxide polimaltozata gland (50 mg iron) + water for injection, sodium hydroxide, hydrochloric acid.

Product form

• Drops for oral Maltofer   - Liquid of dark brown color, with a creamy taste. The drug is released in drops to 30 ml in a vial with the dispenser.
• Syrup   a brown viscous consistency, produced in vials of 150 ml with measuring cup.
• Means in the form of tablets   - In the form of a flat cylinder. Color - brown, with white inclusions risk. Blisters of 10 pieces, pack of 3 blisters.
• Oral solution   also it has a dark brown color.
• The solution for intramuscular injection   is brown, available in 2 ml ampoules, in cardboard packs of 5 ampoules.

Pharmacological action

The preparation of iron deficiency up for it in the body.

Pharmacodynamics and pharmacokinetics

Iron   - It is very important and necessary for the body element. It is part of the Hemoglobin   and myoglobin It performs several important functions in the process metabolism . Iron deficiency leads to anemia .

Thanks to polymaltose complex   more stable and hardly comes into   oxidation Iron is not released into the gastrointestinal tract in the form of ions   Fe3 + . Its structure is most similar to the natural structural element -   ferritin . Due to this, the frequency and the number of possible side effects of the drug is greatly reduced.

Decreases the degree of susceptibility to oxidation Lipoprotein   low and very low density.

Once in the systemic circulation by absorption in the intestine (in the duodenum or small intestine), or direct administration (injection) of iron, having reticuloendothelial system It is stored in the liver. And then, the bone marrow is involved in the formation of hemoglobin, myoglobin, and other elements.

Studies were performed, using the procedure double isotopes Which showed that the extent of selective absorption of iron. If the body, and so there is sufficient material, the absorption rate is extremely low, compared with the state of iron deficiency. The stronger the body lacks iron, the more he learns.

The tool has a low toxicity. Unused iron excreted in the feces, dead cells of the epithelium of the gastrointestinal tract and skin, while breathing in the bile and urine. It should be remembered that women have is a big loss of iron during menstruation.

If it is impossible to use the drug in pill form or another, apply a solution for injection. When administered intravenously one day after injection of the drug reaches maximum concentration in the plasma.

Indications

Tool used:

• for the treatment and prevention iron deficiency anemia , Clearly manifested iron deficiency ;
• for the prevention of people on a strict diet, the elderly, pregnant women, children and adolescents during periods of active growth.

Injections of the drug can be used only after the iron deficiency by examining the composition of the blood (the level Hemoglobin   in blood, erythrocytes gematokrina, serum ferritin ).

Contraindications

The drug is contraindicated in:

• in the presence of hypersensitivity reactions;
• hypoplasia of the bone marrow ;
• in chronic polyarthritis ;
• hemochromatosis, gemosideroze ;
• syndrome   Rendu-Osler-Weber ;
• in violation erythropoiesis ;
• at sideroahresticheskaya anemia . lead anemia . porphyria skin . Thalassemia ;
• if uncompensated cirrhosis   and kidney disease in acute, the latter stages;
• at stenosis   or other diseases   GI ;
• at regular transfusion .

In the presence of diseases gastrointestinal tract It is often used solution for intramuscular injection . It can not be used for intravenous In the first trimester of pregnancy, children up to 4 months. Otherwise contraindications are the same as for the oral forms.

Side effects

Adverse reactions to oral dosage forms:

• pain epigastric . nausea . diarrhea . constipation . vomiting ;
• hives . eczema . anaphylactic reactions ;
• rarely staining enamel black.

Injection, adverse reactions:

• arthralgia ;
• fever   and increased lymph nodes ;
• dyspepsia ;
• allergic reactions ;
• headache .

If the injection was performed properly, the skin may change color, cause inflammation and pain at the injection means.

Instructions on Maltofer (method and dosage)

Receive Mode, the dosage and duration of treatment is determined by the attending physician.

Drops, syrup, tablet or solution is taken orally during or after a meal. Tablets may be chewed or crack, the liquid can be diluted in water or juice.

Drops Maltofer, instructions for use

The daily dosage for iron deficiency anemia :

• for preterm infants is 1-2 drops per one kg bodyweight treatment - 3-5 months;
• for children under one year - 10 to 20 drops per day;
• for children to 12 years - from 20 to 40 drops per day;
• adults, pregnant women and children over 12 years old to take 40-120 drops per day.

In the presence of latent iron deficiency   and for the prevention of:

• children up to 6 years appoint - 10 drops per day;
• children from one year to 12 years - 10-20 drops;
• adults and pregnant women from 20 to 40 drops per day.

Instruction in syrup

With anemia :

• children up to 2 years appoint 5 - 5 ml of syrup per day;
• from one to 12 - 5 or 10 ml;
• adults, pregnant women - from 10 to 30 ml per day.

According to the instructions on the pill Maltofer Vifor Daily dosage for adults with iron deficiency anemia - 1-3 pieces per day. For the prevention or treatment of latent iron deficiency, prescribed one tablet a day. Pregnant women under treatment taken 2-3 tablets per day.

Oral solution, manual

In order to normalize the level of Hemoglobin   in blood (for adults) drink one bottle means 1 or 3 times per day. The course of from 3 to 5 months, the dosage is then reduced to 1 vial. For prevention take 1 bottle for several months. For pregnant women, the dosage will be somewhat higher.

Instructions on injection

The daily dosage and duration of treatment should be determined by the doctor. They are calculated according to the weight of the patient from special tables (in the formula).

Before the first dose should produce test sensitivity. Intramuscularly administered to a half or a quarter of the single dose. In the absence of any side effects of administered liquid remaining in the syringe.

Typically, the daily adult dosage is one ampoule solution. Maximum number of drugs administered during the day:

• for children weighing up to 5 kg - fourth of the vial;
• for children weighing from 5 to 10 kg - half the ampoule;
• 10-50 kg - one vial;
• for adults - two vials.

If after 2 weeks of use have not come improvements in hemodynamic parameters should be adjusted to review the treatment and diagnosis.

Instead of the usual method of administration is recommended ventro-gluteal techniques a . The needle must be thin, no more than 6 cm in length. After the injection, it is recommended to move a little bit like, or foot, to disperse the blood (of medicine) in the body.

Overdose

Chance overdose is extremely small, particularly when oral administration. There were no cases of overdose. Clinical studies have confirmed that even when receiving 2000 mg of iron per kg weight of human being, death is unlikely.

The probability of overdose is increased by means of intramuscular injection. Can acute iron overload occur, the symptoms appear hemosiderosis .

Therapy - according to the developed symptoms reception chelates   ( Deferoxamine   i.v.).

Cooperation

Antacids . vitamin E , Eggs, milk, coffee and black tea, cheese and some cereals may complicate the process of iron absorption in the intestine. Lemon acid   and vitamin C On the contrary reinforce the process.

The plasma concentration   penicillamine , Tetracycline and sulfasalazine   reduced by salts of iron.

Terms of sale

It requires a prescription.

Storage conditions

Keep out of direct sunlight, protected from light and away from children. Temperature range: up to 25 degrees.

Shelf life

5 years. The vials were used immediately after opening.

Cautions

The preparation (especially for oral use) may stain the stool black.

Use caution to patients diabetes   or fructose intolerance .

The drug is not recommended for patients receiving leukemia .

Ampoules with the preparation must not contain any sediment or be damaged. After opening the injection use immediately.

Not recommended intramuscular means children under the age of 4 months.

Analogs

The closest analogues are: Globigen, Sorbifer, Ferumbo, Ferinzhekt, Ferrum Lek, Profer, Ferro-Folgamma.

Is it better or Sorbifer Maltofer?

Both drugs are effective, well absorbed. Some prefer Maltofer, as it causes less side reactions.

Ferro-Folgamma or Maltofer?

The analogue form contains divalent iron, which is slightly less digestible and cause additional side effects. However, in its composition contains folic and ascorbic acid due to enteric coating formulation less irritating to the gastrointestinal tract. Some preferred Ferro Folgamma, despite the fact that it is expensive.

Is it better or Maltofer Ferrum Lek?

Maltofer is more convenient as compared to the analogue form of release - drop. This is especially important for young children. It is believed that Maltofer less likely to cause allergies.

Babies

For children up to 12 years is most appropriate use of the syrup. At the age of about one year it is recommended to change to a drop of syrup for children.

The drug has a positive feedback upon receipt of children, means well absorbed, practically does not cause adverse reactions.

Maltofer during pregnancy and lactation

There have been studies showing that women on 2nd and 3rd trimester of pregnancy receiving funds do not cause disease in the mother or fetus.

Responses to the drug during pregnancy are good. The drug was well raises hemoglobin Seldom causes side reactions. If there was an urgent need to use the tool during lactation, you should consult with your doctor about the advisability continue to breastfeed.

Reviews Maltofer

Reviews of tablets

The drug is well to raise a low hemoglobin in a relatively short period of time. The drug is mostly positive reviews. Side effects are rare, most often   diarrhea   or constipation . Some do not like the unpleasant taste of the syrup or drops in contrast to the odor. After the injection means when improper injection technique sometimes remain dark spots on the skin that are long past.

Reviews for infants

Maltofer quickly and effectively raises hemoglobin and small infants. Parents prefer drops or liquid for oral administration. Often, it is diluted with milk. Side effects occur infrequently.

Price Maltofer where to buy

Cost drops   30 ml - 250 rubles.

Price Syrup   - About 300 rubles per 150 ml.

Cost tablets Maltofer   is 329 rubles per 30 pieces.

Purchase oral solution   it is possible for 406 rubles, 10 vials of 5 ml.

Liquid for intramuscular administration   worth 771 rubles for 5 ampoules of 2 ml.