Description overdue on 05/09/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions on Neyrorubin (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Synonyms
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

Neyrorubin produced in the form of tablets, as well as the solution intended for injections (injections). The chemical composition of one ampoule preparation nominal volume of 3 ml. It contained 100 mg.   thiamine hydrochloride (vitamin B1) and pyridoxine (B6) And 1 mg. cyanocobalamin (B12) .

One tablet Neyrorubina   It contains 200 mg. thiamine mononitrate 50 mg. pyridoxine hydrochloride And 1 mg. cyanocobalamin .

In the tablet Neyrorubina Forte Laktab   200 mg.   thiamine mononitrate,   50 mg. pyridoxine hydrochloride And 1 mg. cyanocobalamin .

In addition, in a preparation contains auxiliary substances such as: powdered cellulose, hypromellose, pregelatinized starch, mannitol, microcrystalline cellulose, magnesium stearate and colloidal silicon dioxide.

Film-coated tablet contains titanium dioxide, Macrogol 6000, erythrosine, talc and hypromellose.

Product form

Tablets Neyrorubina in shell packed into foil blisters of 10 pieces. Typically, one carton contains two blisters.

The solution in the ampoules , Nominal volume of 3 ml., Packed in cartons of 5 pieces each.

Forte Tablets Neyrorubin Laktab   packed in blisters contour of 10 pieces each, and placed in cartons.

Pharmacological action

The drug belongs to a drug containing complex in its composition vitamins . Neyrorubin   and Neyrorubin Forte Laktab   They contain in their composition neurotropic vitamins belonging to group B .   which play an important role in the metabolism of carbohydrates, proteins and fats,   and also participate in metabolic processes .

Pharmacodynamics and pharmacokinetics

The complex of vitamins Neyrorubin contains in its composition water-soluble vitamins B1, B6,   and AT 12 . Despite these vitamin compounds belonging to the same group of useful substances, they are notable for their broad spectrum of biological activity. In addition, each vitamin is responsible for different processes occurring in the human body.

Vitamin B1, for example, takes an active part in metabolism of carbohydrates, fats,   and moreover   proteins. At deficiency thiamine   in the body increases the level pyruvic,   and lactic acid . Helpful Links Through the process transamination   and deamination   irreplaceable amino acids .

It is thus Vitamin B1   normalizes proteometabolism . It should be noted that the substance acts as a catalyst in the process fat metabolism and education fatty acids Stimulates   secretory function and intestinal peristalsis And interacts with cell membranes in neurons and activate ion channels.

Vitamin B6   as IN 1 It takes an active part in the metabolism of proteins and fats As well as the synthesis of enzymes . This is a useful compound for the human body acts as a coenzyme in reactions fermentalnyh . Pyridoxine promotes formation neural myelin membrane as well as taking part in the protein and lipid metabolism, the synthesis of hemoglobin and neurotransmitters in the synapses of the central and peripheral nervous system.

Cyanocobalamin   It plays an important role in protein metabolism And regulates the production of nucleic acid purines And moreover amino acids . Such a compound is cyanocobalamin   vital to the organism, because the substance has an effect on the production of acetylcholine As well as for myelination of neurons . On top of this vitamin compound has a positive effect on regeneration of nerve fibers , and It stimulates peripheral nerve structures in the production of pulses.

The substance has on the human body hematopoietic effect , Regulates the level of   cholesterol And stimulates erythropoiesis. Cyanocobalamin   improves hematopoiesis and normalizes the velocity clotting . All together vitamins B1, B6 and B12   contribute to the normalization of the Nervous System   human, and in addition, have a positive impact on protein, lipid, fat and carbohydrate metabolism.

It is worth noting also the fact that the combination of vitamin compounds facilitates pain during   neurological diseases different genesis . Pharmacokinetics Neyrorubina depends on the distinctive properties of vitamin compounds that make up the drug.

After taking the drug intestine, jejunum and duodenum going absorption of thiamine . A small number of Vitamin B1   digest liver   then the beneficial agent is metabolized and decomposed into Pyramin , and thiamine-carboxylic acid . Thiamin   excreted from the body through kidney and intestine Both in unchanged form and as metabolites .

Pyridoxine hydrochloride absorbed in the intestine , and then metabolized in the body and breaks to   pyridoxamine, pyridoxal-5-phosphate   acting as and coenzyme pyridoxal   (active   metabolites vitamin compounds).

AT itamin B6 It is characterized by its close relationship with proteins Contained in plasma . Connection bioaccumulates in muscle, liver, as well as organs of the nervous system . Pyridoxine   excreted from the body by means of kidney as well as   Thiamine (B1) in the same composition or as active metabolites.

In normal   absorption of vitamin B12 , Helpful Links metabolized   and transformed into adenosylcobalamin . Compound output through the bile and urine, as well as cumulated in the liver.

Indications

The first tablet form such as a drug Neyrorubin   and Neyrorubin Forte Laktab   is used as a preventive measure in conditions which are characterized by deficiency of B vitamins As well as complex therapy in treating diseases such as:

• polyneuritis ;
• neuritis ;
• neuralgia ;
• intoxication Including alcohol;
• diabetic polyneuropathy .

Injection Neyrorubin used singly monotherapy and as part of a therapeutic treatment of diseases such as:

• gipovitaminoz ;
• diabetic polyneuropathy ;
• beriberi   (either wet or dry form of the disease);
• neuritis , Including acute and chronic forms of the disease;
• neuralgia ;
• polyneuritis .

Contraindications

Both drugs are contraindicated for the following diseases:

• pregnancy ;
• allergic diathesis;
• lactation ;
• hypersensitivity   Chemical composition of the drug;
• age 18 years.

These drugs may complicate psoriasis And exacerbate acne .

Side effects

When receiving Neyrorubina Forte and Forte Neyrorubin Laktab may experience the following side effects of drugs:

• vomiting ;
• an increase in blood levels Hepatic transmiaz ;
• nausea ;
• stomach bleeding ;
• headache ;
• increased   irritability;
• causeless anxiety ;
• dizziness ;
• anxiety ;
• sensory neuropathy ;
• tachycardia ;
• circulatory collapse ;
• pulmonary edema ;
• itching ;
• development acne;
• hives ;
• a rash on the skin;
• increased sweating ;
• cyanosis ;
• angioedema ;
• anaphylactic shock .

Instructions on Neyrorubin (method and dosage)

The dosage of the drug, as well as the duration of the course of therapeutic treatment, the doctor determines, based on the nature of the disease and the patient's condition. In accordance with the instruction for Neyrorubin Forte Tablets taken after, before or during a meal, not chewing and drinking water, preferably boiled and the room temperature.

For adult patients a set average therapeutic dose is 1-2 tablets per day. Generally, treatment Neyrorubinom an average of one month.

In accordance with the instruction Neyrorubina, injections made to remove pain depending on the severity of the disease every day or once in two days. The solution in the ampoules intramuscularly into gluteal muscles . When the patient's condition improves, to maintain the effect of the drug is recommended to be administered by intramuscular injection of 3 ml. Neyrorubina a couple of times a week.

Overdose

Usually, an overdose of the drug in patients exacerbated side effects. In this situation, it is shown holding a gastric lavage to a patient as well as symptomatic therapy.

Cooperation

It does not take together Neyrorubin, Levodopa   and Altretamine As vitamin complex reduces the effectiveness of the above drugs. To avoid toxicity gain Isoniazid   It should not simultaneously use the drug and the complex B vitamins .

It should be remembered that antagonists of vitamin B1   are substances such as Fluorouracil,   and thiosemicarbazone . Absorbance Neyrorubina Forte Laktab   reduce preparations having antacid properties and providing enveloping effect .

Terms of sale

OTC.

Storage conditions

Keep out of the reach of children, at a temperature not exceeding 25 ° C.

Shelf life

4 years.

Cautions

Particular care should be taken vitamin complex to patients Heart Failure , and angina.   Very rarely, however, is chronic administration of drugs that a high daily dosage of the drug causes patients develop sensory neuropathy,   which disappears immediately after the cessation of the use Neyrorubina.

While taking the medicine need to be careful while driving or working with potentially dangerous machinery, since the drug causes side effects such as   weakness, dizziness,   and causeless anxiety , and alarm .

Analogs Neyrorubina

Among the analogues of vitamin complex are the following products:

• Vitakson ;
• Neyrobion ;
• Neurovitan;
• Neyromultivit ;
• Nervipleks ;
• Neurobeks ;
• Yunigamma .

Synonyms

Neurorubine.

Babies

The drug is not recommended for use in patients under 18 years.

During pregnancy and lactation

Since the data for the complete safety of the drug pregnant   and nursing women do not have, Neyrorubin not be used for the above periods. However, the doctor may prescribe this vitamin complex in the case of a pregnant woman acute medically necessary and only with the expectation that the anticipated benefits would be considerably higher than harm.

If necessary, use during Neyrorubina Lactation It should stop breast-feeding Because the compound overcomes   blood-placenta barrier   and changes the composition of breast milk, which can adversely affect the health of the child.

Reviews Neyrorubine

As a rule, patients leave positive feedback to Neyrorubin, noting the effectiveness of the drug. However, some complain of side effects such as skin rashes, itching and other allergic reactions .

Price Neyrorubina where to buy

The cost of the complex B vitamins depends primarily on the form of medication, as well as region of the country. For example, one pack of ampoules of the drug will cost about 500 rubles. Price Neyrorubina in Kharkov (injection) is an average of 90 hryvnia.