Description overdue on 06/08/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use FLEX (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Babies
• Reviews
• Price, where to buy

Composition

• Ketoprofen ;
• soybean oil hydrated;
• vegetable oil;
• beeswax;
• hydrogenated vegetable oil;
• soy lecithin;
• gelatin;
• titanium dioxide;
• sorbitol;
• glycerol;
• sodium propyl parahydroxybenzoate;
• sodium ethyl parahydroxybenzoate.

Product form

Capsules . Oblong opaque gelatin soft capsules. Color pale yellow. The capsules contain a cream-colored oily suspension structure. Issue: 6 pcs. in the plate. Packaging - 2 plate in a carton box.

Rectal suppositories (suppository) . Oily feel suppositories shaped torpedo. Colour white or white - silicon Content of ketoprofen - 100 mg. Issue: 6 pieces per strip. Packaging - 2 strips are in a carton box.

Gel . The clear homogeneous gel. Colourless. Content of ketoprofen - 25 mg. Release: Tubes - 30 and 50g. The cardboard package - one envelope.

The ampules . Package: 1 vial containing lyophilized powder FLEX (homogeneous mass of white) + 1 vial of solvent (water for injections and benzyl alcohol) Issue: 6 sets in a carton box.

Pharmacological action

It has anti-inflammatory, analgesic, and antipyretic effect antiagregatine.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The main component of an ingredient of the drug - Ketoprofen Which refers to non-steroidal anti-inflammatory agents (NSAIDs) . The inhibitory effect of flexion activates enzymes cyclooxygenase-1 . This process prevents the formation of inflammatory mediators and inhibits the emergence of leukotrienes.

During use of the drug, there is a persistent decline in activity of neutrophils and stabilize the state of the membranes of lysosomes. FLEX penetrates deep into the cerebrospinal fluid and synovial membrane coupling.

Pharmacokinetics

With intramuscular injection, while the development of higher plasma concentrations of 15-30 minutes. Protein binding of blood - 99%, bioavailability - 90% and more. After the start of the regular reception of flexion, the mean plasma concentration occurs within 24 hours. A therapeutic concentration is kept in the synovial fluid for 6-8 hours.

There metabolism in the liver by a rapprochement with glucuronic acid. The process occurs in half-life for 1, 5 - 2 hours.

Indications

FLEX is designed for the symptomatic treatment of the following inflammatory processes:

• thrombophlebitis ;
• phlebitis ;
• problems lumbosacral plexus;
• joint pain;
• lymphangitis ;
• rheumatoid arthritis ;
• acute pain;
• peritendinitis ;
• lymphangitis ;
• stretching;
• gout ;
• ligament damage;
• sciatica ;
• dislocation ;
• synovitis ;
• dorsalgia ;
• radiculitis ;
• renal colic ;
• bone pain;
• postoperative pain;

Contraindications

The drug should not be used in the following cases:

• aggravation of gastrointestinal diseases;
• bleeding   in the gastrointestinal tract;
• acute disorders of the liver;
• acute kidney damage;
• disorders in the blood, including leukopenia . hemophilia . thrombocytopenia ;
• expressed heart failure ;
• localization of pain before or after surgery of the cardiovascular system;
• pregnancy and lactation;
• hypersensitivity to NSAIDs.

FLEX should be used with caution in patients with dysfunction of the gastrointestinal tract, kidney, liver, asthma . hives . rhinitis , Blood diseases, cirrhosis . diabetes . sepsis , Cerebrovascular diseases.

Side effects

Central and peripheral nervous system : migraine . headache . insomnia . dizziness . depression . nervousness . asthenia . drowsiness . peripheral neuropathy .

Digestive system : Stomach pain, vomiting, nausea, flatulence . diarrhea , Gingival, and hemorrhoidal bleeding, increased liver transaminases in blood serum, perforation gastrointestinal mucosa.

Respiratory system : breathlessness . bronchospasm , Edema of the larynx, nosebleed . hemoptysis . rhinitis . dispnoz .

Cardiovascular system : High blood pressure, tachycardia .

The urinary system : Disruption of the kidney, urethritis . cystitis , Edema, nephrotic syndrome . hematuria .

Senses : Ccomodation clarity and vision, tinnitus, conjunctivitis , Hearing loss.

Hematopoietic system : leukopenia . anemia . thrombocytopenia . agranulocytosis .

Allergic reactions : itchy skin , skin rash, exudative erythema . Stevens-Johnson syndrome . angioedema . photodermatitis . anaphylactic shock .

Other symptoms: eczema , Muscle-teak, sweating, thirst, myalgia . vaginal bleeding .

Instructions for use FLEX (method and dosage)

The capsules of the drug FLEX   swallowed whole, without chewing, drinking water (50 - 100 g). The drug is taken after a meal. The dosage varies from 2 to 6 capsules a day, depending on the doctor's prescription.

Instructions for use of candles FLEX

This form of the drug is used rectally. The daily dose of 1 - 2 suppository.

Instructions on the gel

Ointment is applied topically, and small amounts of a thin layer. The substance is slightly rubbed over the fire of inflammation. The procedure is carried out rubbing 2 - 3 times a day. The course of treatment should not last more than 2 weeks. Further application must be approved by your doctor.

Injections FLEX   carried deep into the muscle tissue. A dose of 100 mg of 1 or 2 times per day. After the elimination of acute pain, it is possible to switch to the use of capsules or suppositories. The maximum dose injections per day - 300 mg.

Overdose

An overdose of the drug is expressed in the following forms: bleeding, drowsiness, nausea, disruption of the kidney and liver , Epigastric pain .

Therapeutic treatment is performed by washing the stomach and using the adsorbents. Subsequent treatment depends on the individual patient's condition.

Cooperation

The results of the interaction of flexo with the following medications:

• Antithrombotic drugs   - Improving the efficiency of antithrombotic drugs.
• Antagonists By vinamina   - It increases the performance of these antagonists.
• Substances containing ethanol   - Enhances the effect of alcohol, leading to the risk of bleeding in the gastrointestinal tract.
• Preparations containing lithium   - Strengthening effect of lithium-containing substances.
• Enhancing Heparin .
• Increases toxicity Methotrexate .
• Enhancing klyukortikoidov .
• Reduction Actions peripheral vasodilators .
• Reduction Actions spironolactone .
• Incompatibility tramadol .
• Increased efficiency ticlopidine .
• Increased side effects of estrogen with estrogenic drugs.
• Increased risk of bleeding with Tsefamandol .
• The risks of gastrointestinal ulceration interaction with NSAIDs.
• Destabilization of platelet aggregation with valproic acid .
• Antacids reduce the absorption efficiency flexion.
• Kolestiramin   It decreases the absorption of flexion.
• Myelotoxicity substance   enhance the haematotoxicity.

Terms of sale

The drug is released under the FLEX prescription.

Storage conditions

The drug should be stored at temperatures up to + 25 degrees C. This temperature range applies to all forms of release.

Shelf life

Shelf life of all forms of flexi issue is - 3 years.

Cautions

During treatment it is necessary to exercise control the functional state of the kidneys and liver and As well as to monitor the state of peripheral blood .

No alcohol.

With violation of   should consult an ophthalmologist.

During the reception FLEX, should be careful in dealing with complex mechanisms driving vehicle, as well as works that require fast psychomotor reactions.

Analogs

Artrum, Artrozilen, Bystrumkaps, Bystrumgel, Valusal, Ketonal, Ketosprey, Ketoprofen, Oruvel, Profenid, Flamaks, Fastum, Febrofid.

Babies

Children and adolescents under 18 years of age is not recommended the use of FLEX.

Reviews Fleksene

Reviews FLEX injections   positive. Many patients suffering   radiculitis and applying this drug, suggest that the pain goes away after 10 - 15 minutes after the injection.

Flexi Gel   simply irreplaceable at back pain So many people characterize the gel to apply it in practice.

Reviews of candlelight in gynecology

FLEX is indicated for ovarian cysts . According to the testimony of many women, the drug acts very effectively. Fleksenom After treatment for 10 days and subsequent reception of additional means cyst disappears. Candles flexion in gynecology in high demand and are popular.

Price flexion, where to buy?

Cost candles FLEX : 188 - 221 rubles. Package solution for intramuscular injection : 190 - 230 rubles. Capsules FLEX   - 30 pcs. 50 mg: 156 - 190 rubles. Flexi Gel   for outdoor use 1 pc. 2, 5%: 152 - 195 rubles. The drug is sold in pharmacies by prescription.