Description overdue on 05/20/2013

Anti-inflammatory, anti-microbial intestinal drug . Active veschetsvo - mesalazine . The large intestine is shown antibacterial activity of the drug in respect of most types of cocci and E. coli. The mechanism of action is based on reducing the rate of degranulation, and phagocytosis of neutrophil migration, on slowing the secretion immunoglobulins   blood cells lymphocytes. The local anti-inflammatory effect is achieved by inhibiting the synthesis of leukotrienes and prostaglandins, reduce neutrophil activity lipooksidazy. The antioxidant effect is provided by the ability to bind mesalazine with oxygen free radicals and their subsequent destruction. Pentas drug is well tolerated. Patients with ileitis , The chronic course of Crohn's disease medication can significantly reduce the risk of recurrence. Pentasil is produced in the form of rectal suppository, in tablet dosage form.

Indications:

Tablets prescribed for Pentas Crohn's disease When nespetseficheskom variants of ulcerative colitis. The drug can be used as a prophylactic measure.

Contraindications:

Pentas is not indicated during breastfeeding, with ulcers of the digestive tract, diseases of the blood, if you are hypersensitive mesalazine. Instructions for use of the drug is not recommended for Pentas medication to children under two years old, with severe liver diseases and diseases of the liver and, if carrying a pregnancy (last 2-4 weeks).

Side effect:

Digestive system: stomatitis , Dry mouth, nausea, decreased appetite, heartburn . vomiting . diarrheal syndrome . hepatitis . increase in liver enzymes . pancreatitis . Cardiovascular system:   shortness of breath during physical activity, blood pressure fluctuations, tachycardia , Chest pain, a feeling of palpitations. Nervous system:   tremor of limbs, polyneuropathy, vertigo, tinnitus, depressed mood, migraine headaches. Urinary system: crystalluria, hematuria, proteinuria (urinary protein) anuria   (no urination), oliguria, formation of nephrotic syndrome. Bodies of blood: gipoprotrombinemii , Leukopenia, eosinophilia, thrombocytopenia, anemia (options: aplastic, megaloblastic, hemolytic), diagnosis of agranulocytosis. Also, the intake of the drug may cause alopecia Pentas, formation photosensitivity , Olisgospermii, volchanochnopdobnogo syndrome, mumps, weakness in limbs, decrease in production of tear fluid.

Overdose:

It is characterized by excessive sleepiness,   stomachalgia , Nausea, vomiting, weakness throughout the body. Timely gastric lavage, holding posindromnoy therapy appointment laxative medicines .

Mode of application:

Depending on the extent of intestinal lesions, locating basic process depends on the choice of dosage form. Pentas candles prescribed for distal forms of the disease: proctosigmoiditis . Pentas pills are recommended for common forms of disease. Prevention of relapse in Crohn's disease Four times a day by 1 gram of mesalazine. Prevention of relapse of ulcerative colitis:   three times a day, 400-500 mg. The aggravation of the disease: The course is designed for 8-12 weeks with a daily intake of 400-800 mg three times Pentas. Perhaps an increase in the daily dose of 3-4 grams in severe disease. Pentas is recommended to take tablets after meals, without chewing, drinking plenty of water. Pentasil suppositories administered three times a day at 500 mg.

Special instructions:

Responses to the drug Pentas demonstrate high efficiency of mesalazine in the treatment and prevention of nespetseficheskogo ulcerative colitis, Crohn's disease. When skipping the missed dose mesalazine medication is recommended to take the next dose with or in the near future. If you pass multiple doses recommended an urgent appeal to the doctor; not allowed independent discontinuation of treatment. In some cases the staining contact lenses and urine yellowish orange shade. Requires regular control over the renal system, it is necessary to analyze urine, blood, throughout the course of treatment and on its completion. The probability of side effects increases in patients who are " slow acetylators ". In the formation of an acute intolerance syndrome active component drug Pentas overturned. The price of the drug Pentas vary by region, the pharmacy chain (an average of about 2000 rubles ). Recommended temperature storage of medication 25 degrees Centigrade . Analogs of the drug Pentas: mesakol . salofalk . salozinal . mezavant . Asacol . mesalazine .

Drug Interactions:

Pentas slows absorption of cyanocobalamin. Mesalazine can increase the effectiveness of uricosuric medications (blockers of tubular secretion). The drug enhances the toxicity Methotrexate , Hypoglycemic effect of sulfonylureas weakens the effectiveness of rifampin, sulfonamides, spironolactone, furosemide. Pentas increases ulzerogennosti glucocorticosteroids.